00 Male Issues Flashcards

1
Q

What is the normal range for Prostate Specific Antigen (PSA)?

A

0-4 ng/mL

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2
Q

What are some medications that may worsen BPH?

A

Anticholinergics (TCAs, antipsychotics, etc), Antihistamines, Decongestants, Diuretics, Caffeine

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3
Q

What is the generic name of Hytrin?

A

Terazosin - BPH (Non-selective Alpha-1 blocker)

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4
Q

What is the generic name of Cardura?

A

Doxazosin - BPH (Non-selective Alpha-1 blocker)

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5
Q

What is the generic name of Uroxatral?

A

Alfuzosin - BPH (Non-selective Alpha-1 blocker)

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6
Q

What is the generic name of Flomax, Jalyn?

A

Tamsulosin - BPH (Selective Alpha-1a blocker)

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7
Q

What is the generic name of Rapaflo?

A

Silodosin - BPH (Selective Alpha-1a blocker)

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8
Q

What is important to know about Alpha-1 blockers in BPH?

A

1st dose phenomenon (orthostatic hypotension), dose at night. Does NOT affect PSA levels nor shrink the prostate. Can cause Priapism

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9
Q

What is important to know about 5-alpha reductase inhibitors in BPH?

A

Associated with prostate SHRINKAGE and symptom improvement. Delayed onset of response vs alpha blockers

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10
Q

What is the generic name of Proscar?

A

Finasteride - BPH (5-alpha reductase inhibitor)

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11
Q

What is the generic name of Avodart, Jalyn?

A

Dutasteride - BPH (5-alpha reductase inhibitor)

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12
Q

What pregnancy category are the 5-alpha reductase inhibitors used for BPH?

A

Category X

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13
Q

What are the main ADRs for 5-alpha reductase inhibitors for BPH?

A

Sexual dysfunction, Breast swelling and tenderness

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14
Q

What is the generic name of Viagra?

A

Sildenafil (PDE-5 inhibitor)

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15
Q

What is the generic name of Cialis?

A

Tadalafil (PDE-5 inhibitor)

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16
Q

What is the generic name of Levitra?

A

Verdenafil (PDE-5 inhibitor)

17
Q

What is the generic name of Stendra?

A

Avanafil (PDE-5 inhibitor)

18
Q

When are PDE-5 inhibitors contraindicated?

A

With Nitrates!

19
Q

What are some unusual ADRs with PDE-5 inhibitors?

A

Transient abnormal blue/green vision (mostly with Sildenafil). Sudden vision loss d/t nonarteritic ischemic optic neuropathy (NAION). Priapism

20
Q

What is the generic name of Rogaine?

A

Minoxidil (used for baldness) - increases blood flow to hair

21
Q

What is the generic name of Propecia?

A

Finasteride (used for baldness) - inhibits testosterone –> DHT

22
Q

Which baldness medication can be used in both men and women?

A

Rogaine (Minoxidil)

23
Q

What are some medications that can induce hypogonadism?

A

Ketoconazole, Glucocorticoids, Spironolactone, Cimetidine, Phenytoin, Opioids, Alcohol, Anabolic steroids, Flutamide

24
Q

What type of allergy should Androgel, Striant, Testim be avoided in?

A

Soy

25
Q

What are the two oral medications that can be used for hypogonadism?

A

Methyltestosterone or Fluoxymesterone

26
Q

What are the oral preparations limitations for hypogonadism?

A

Poor oral bioavailability, Poor androgen effect, Adverse lipid changes, Priapism, Increased risk of hepatic side effects

27
Q

What is the generic name of Striant?

A

Testosterone buccal preparation - used for hypogonadism

28
Q

What are the advantages of testosterone buccal preparation (Striant)?

A

BID dosing allows for normal testosterone levels throughout the day

29
Q

What is the generic name of Androderm?

A

Testosterone transdermal patch (for hypogonadism). Should be applied in the evening, if it falls off you may press back on or replace before noon

30
Q

Where can Androderm patch be placed?

A

Upper arms or back. Abdomen. Thighs

31
Q

What are the advantages of using Androderm?

A

Closely mimics normal diurnal changes in testosterone levels

32
Q

What is the generic name of AndroGel?

A

Testosterone gel formulation

33
Q

What is the generic name of Testim?

A

Testosterone gel formulation

34
Q

Where can AndroGel be applied?

A

Upper arms or Abdomen

35
Q

Where can Testim be applied?

A

Upper arms only

36
Q

What is the generic name of Fortesta?

A

Testosterone gel formulation

37
Q

Where can Fortesta be applied?

A

To the thighs only!

38
Q

What is the generic name of Axiron?

A

Testosterone topical formulation used in armpit, apply deodorant first

39
Q

What should a patient do to minimize first-dose syncope with terazosin?

A

Start with 1mg daily