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Board Study Topics > 00 Anticoagulation > Flashcards

00 Anticoagulation Flashcards

1
Q

What are the indications for Unfractionated Heparin?

A

ACS, VTE Treatment, VTE Prophylaxis

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2
Q

What is Unfractionated Heparin dosing like for ACS?

A

Bolus: 60 units/kg IV. Drip: 12 units/kg/hr IV. Use actual body weight

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3
Q

What is Unfractionated Heparin dosing like for VTE Treatment?

A

Bolus: 80 units/kg IV. Drip: 18 units/kg/hr IV. Use actual body weight

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4
Q

What is Unfractionated Heparin dosing like for VTE Prophylaxis?

A

5000 units SQ BID-TID

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5
Q

What are the goal levels for Unfractionated Heparin?

A

Adjust per PPT goal (~1.5-2.5x baseline)

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6
Q

How are the effects of Unfractionated Heparin reversed?

A

Protamine (1mg ~100 units heparin; max 50mg, give over 10 minutes)

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7
Q

What is the generic name of Lovenox?

A

Enoxaparin (LMWH)

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8
Q

What are the indications for Lovenox?

A

DVT prophylaxis, DVT treatment, STEMI, Non-STEMI

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9
Q

What is a usual dose for Lovenox when being used for a DVT prophylaxis?

A

Usually 30mg SQ Q12h OR 40mg SQ daily

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10
Q

What is Lovenox dosing like for DVT Treatment?

A

1mg/kg SQ Q12h OR 1.5mg/kg SQ daily

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11
Q

When do you need to adjust the Lovenox dose?

A

For renal impairment. Once CrCl < 30 you need to go do the daily dosing (30mg SQ daily for prophylaxis or 1mg/kg SQ daily for treatment)

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12
Q

What are the contraindications to Lovenox use?

A

History of HIT. Active bleed. Allergy to pork

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13
Q

What is the generic name of Innohep?

A

Tinzaparin (LMWH)

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14
Q

When is Innohep (Tinzaparin) contraindicated?

A

Sulfite allergy

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15
Q

What is the generic name of Fragmin?

A

Dalteparin (LMWH)

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16
Q

What is the generic name of Arixtra?

A

Fondaparinux (Factor Xa Inhibitor)

17
Q

What is Arixtra (Fondaparinux) approved for?

A

DVT prophylaxis. DVT/PE Treatment

18
Q

What is the dosing of Arixtra (Fondaparinux) for DVT prophylaxis?

A

2.5mg SQ daily

19
Q

What is the dosing of Arixtra (Fondaparinux) for DVT/PE prophylaxis?

A

< 50kg: 5mg SQ daily
50-100kg: 7.5mg SQ daily
> 100kg: 10mg SQ daily

20
Q

When is Arixtra (Fondaparinux) contraindicated for DVT prophylaxis?

A

In patients < 50kg

21
Q

What dose adjustment is required for Arixtra (Fondaparinux)?

A

If CrCl < 30: USE IS CONTRAINDICATED

22
Q

What is the only non-PO Factor Xa Inhibitor?

A

Arixtra (Fondaparinux, given SQ)

23
Q

What is the generic name of Xarelto?

A

Rivaroxaban (Factor Xa Inhibitor)

24
Q

What is the generic name of Eliquis?

A

Apixaban (Factor Xa Inhibitor)

25
Q

What is the BBW with Xarelto (Rivaroxaban)?

A

D/c of Rivaroxaban in patients with non-valvular A.fib can put patients at increased risk of thrombotic events, like stroke

26
Q

What is the BBW with Eliquis (Apixaban)?

A

If Apixaban is being used to prevent stroke in A.fib patients, an increased risk of stroke may occur upon Apixaban d/c

27
Q

What is the generic name of Pradaxa?

A

Dabigatran (Direct Thrombin Inhibitor)

28
Q

What is an ADR you need to be cautious about with Pradaxa (Dabigatran)?

A

Gastritis and GI bleeding

29
Q

Which DTI requires hepatic adjustment?

A

Argatroban

30
Q

What is the generic name of Angiomax?

A

Bivalirudin (DTI)

31
Q

Which factors does Warfarin inhibit?

A

SNOT: 7, 9, 10, 2

32
Q

What are the normal goals with Warfarin dosing?

A

Most indications: 2-3.

Mechanical mitral valve replacement: 2.5-3.5

33
Q

When is Warfarin contraindicated?

A

Pregnancy Category X

34
Q

What pharmacologic considerations should be made with Warfarin?

A

VKORC1 and CYP2C9

35
Q

What are the Warfarin colors/doses?

A

Please Let Greg Brown Bring Peaches To Your Wedding: Pink (1), Lavender (2), Green (2.5), Brown (3), Blue (4), Peach (5), Teal (6), Yellow (7.5), White (10). All in mg

36
Q

When does vitamin K need to be administered?

A

Supra-therapeutic INR > 10 (2.5mg PO x1). Any signs of bleeding (5-10mg IV + PCC/Factor 7)

Board Study Topics (38 decks)

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