00 Drugs in Pregnancy Flashcards
What is preeclampsia?
Condition during pregnancy characterized by worsening hypertension and proteinuria
What is eclampsia?
An acute and life-threatening complication of pregnancy characterized by seizures
What are some examples of Pregnancy Category A drugs?
Levothyroxine, Folic Acid, Riboflavin
What is Lithium use like in pregnancy?
Avoid if possible during first trimester, causes Ebstein’s anomaly (valve abnormally formed in heart). Pregnancy category D
What can Carbamazepine and Valproic Acid cause?
Spina bifida
What medication has been suspected as a risk factor for Autism Spectrum Disorder (ASD)?
VPA
What are some “X-Rated” Drugs?
Isotretinoin, Statins, Live vaccines, MTX, Finasteride, Medroxyprogesterone, Ribavirin, Temazepam, Triazolam, Quinine, Misoprostol, Mifepristone
Which medication is in the iPLEDGE program?
Isotretinoin
Which medication is in the STEPS program?
Thalidomide. STEPS: System for Thalidomide Education and Prescribing Safety
What is the generic name for Arava?
Leflunomide (for RA)
What needs to be done upon d/c of Arava (Leflunomide)?
It is recommended that all women of childbearing potential undergo drug elimination procedure (Cholestyramine 8g PO TID for up to 11 days)
What is the generic of Mifeprex?
Mifepristone (RU-486). Used with Misoprostol (Cytotec). Used for termination of pregnancy up to 49 days
What are some common medications that should not even be handled by pregnant people?
5-alpha reducatse inhibitors (Proscar, Propecia, Avodart). Testosterone (Androgel, Androderm). MTX, Ribavirin, Ganciclovir
What are some drugs that can be used during pregnancy to help with high BP?
Mainly: Labetalol, Methyldopa, Nifedipine. Metoprolol and Pindolol are reported safe
Which BP medications are contraindicated during pregnancy?
ACE-I, ARB, Direct Renin Inhibitor (e.g., Aliskiren, Tekturna)
What is the DOC for analgesia in pregnancy?
APAP. Avoid ASA, all NSAIDs in 3rd trimester
What are the safe anti-infective agents in pregnancy?
Amoxicillin, PCN, Cephalosporins, Clindamycin, Erythromycin, Azithromycin, Dicloxacillin
What are the safe CNS drugs in pregnancy?
Haloperidol, Atypical APs, Zolpidem, Zaleplon, Methadone
What CNS drugs need to be avoided in pregnancy?
Ergots, CBZ, VPA, BZD hypnotics (not all BZDs), MAOI’s, Paxil
What are the safe Pulmonary drugs in pregnancy?
Inhaled corticosteroids, theophylline, montelukast
What is the DOC for diabetes in pregnancy?
Insulin. AVOID sulfonylureas
What are the safe drugs for cough/cold in pregnancy?
Dextromethorphan, Guaifenesin, Loratadine, Chlorpheniramine, Diphenhydramine
What are the safe drugs for GI issues in pregnancy?
H1&2 antagonists (eg. Doxylamine), Antacids, Ginger, Docusate, ~simethicone
What GI drugs need to be avoided in pregnancy?
Metoclopramide, Prochlorperazine, Promethazine, Kaopectate (bismuth subsalicylate)
