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Board Study Topics > 00 Drugs in Pregnancy > Flashcards

00 Drugs in Pregnancy Flashcards

1
Q

What is preeclampsia?

A

Condition during pregnancy characterized by worsening hypertension and proteinuria

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2
Q

What is eclampsia?

A

An acute and life-threatening complication of pregnancy characterized by seizures

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3
Q

What are some examples of Pregnancy Category A drugs?

A

Levothyroxine, Folic Acid, Riboflavin

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4
Q

What is Lithium use like in pregnancy?

A

Avoid if possible during first trimester, causes Ebstein’s anomaly (valve abnormally formed in heart). Pregnancy category D

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5
Q

What can Carbamazepine and Valproic Acid cause?

A

Spina bifida

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6
Q

What medication has been suspected as a risk factor for Autism Spectrum Disorder (ASD)?

A

VPA

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7
Q

What are some “X-Rated” Drugs?

A

Isotretinoin, Statins, Live vaccines, MTX, Finasteride, Medroxyprogesterone, Ribavirin, Temazepam, Triazolam, Quinine, Misoprostol, Mifepristone

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8
Q

Which medication is in the iPLEDGE program?

A

Isotretinoin

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9
Q

Which medication is in the STEPS program?

A

Thalidomide. STEPS: System for Thalidomide Education and Prescribing Safety

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10
Q

What is the generic name for Arava?

A

Leflunomide (for RA)

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11
Q

What needs to be done upon d/c of Arava (Leflunomide)?

A

It is recommended that all women of childbearing potential undergo drug elimination procedure (Cholestyramine 8g PO TID for up to 11 days)

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12
Q

What is the generic of Mifeprex?

A

Mifepristone (RU-486). Used with Misoprostol (Cytotec). Used for termination of pregnancy up to 49 days

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13
Q

What are some common medications that should not even be handled by pregnant people?

A

5-alpha reducatse inhibitors (Proscar, Propecia, Avodart). Testosterone (Androgel, Androderm). MTX, Ribavirin, Ganciclovir

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14
Q

What are some drugs that can be used during pregnancy to help with high BP?

A

Mainly: Labetalol, Methyldopa, Nifedipine. Metoprolol and Pindolol are reported safe

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15
Q

Which BP medications are contraindicated during pregnancy?

A

ACE-I, ARB, Direct Renin Inhibitor (e.g., Aliskiren, Tekturna)

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16
Q

What is the DOC for analgesia in pregnancy?

A

APAP. Avoid ASA, all NSAIDs in 3rd trimester

17
Q

What are the safe anti-infective agents in pregnancy?

A

Amoxicillin, PCN, Cephalosporins, Clindamycin, Erythromycin, Azithromycin, Dicloxacillin

18
Q

What are the safe CNS drugs in pregnancy?

A

Haloperidol, Atypical APs, Zolpidem, Zaleplon, Methadone

19
Q

What CNS drugs need to be avoided in pregnancy?

A

Ergots, CBZ, VPA, BZD hypnotics (not all BZDs), MAOI’s, Paxil

20
Q

What are the safe Pulmonary drugs in pregnancy?

A

Inhaled corticosteroids, theophylline, montelukast

21
Q

What is the DOC for diabetes in pregnancy?

A

Insulin. AVOID sulfonylureas

22
Q

What are the safe drugs for cough/cold in pregnancy?

A

Dextromethorphan, Guaifenesin, Loratadine, Chlorpheniramine, Diphenhydramine

23
Q

What are the safe drugs for GI issues in pregnancy?

A

H1&2 antagonists (eg. Doxylamine), Antacids, Ginger, Docusate, ~simethicone

24
Q

What GI drugs need to be avoided in pregnancy?

A

Metoclopramide, Prochlorperazine, Promethazine, Kaopectate (bismuth subsalicylate)

25
Q

What laxatives are ok to recommend in pregnancy?

A

DOC: Psyllium, DOSS. Recommend: increase fluid and fiber intake. AVOID: Mineral oil and Caster oil

26
Q

What is the preferred PPI in pregnancy?

A

Lansoprazole

27
Q

What are the preferred H2 antagnoists/blockers in pregnancy?

A

Cimetidine and ranitidine

28
Q

What topical drugs for acne are considered safe in pregnancy?

A

Benzoyl peroxide, Clindamycin, Erythromycin

29
Q

What is Diclegis?

A

Combination drug for morning sickness (Doxylamine and Pyridoxine (vitamin B6)). Pregnancy Category A

30
Q

What medications are ok to use for morning sickness?

A

Diclegis, Premesis RX (ginger, doxylamine, pyridoxine), Emetrol, Ginger

31
Q

How often should TSH be checked during pregnancy?

A

Every 4 weeks for first 20 weeks gestation. Check TSH once between 26-32 weeks gestation at least. Check TSH at 6 weeks postpartum

32
Q

Which drugs should generally be avoided during lactation?

A

DA agonists (eg, Bromocriptine, Levodopa), Ergot derivatives, CSA, MTX (immunosuppression), Lithium, Chloramphenicol, Quinolones, “Street” drugs

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