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Board Study Topics > 00 Arthritis > Flashcards

00 Arthritis Flashcards

1
Q

What is the DOC for osteoarthritis?

A

APAP

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2
Q

What are some Diclofenac Topicals?

A

Flector patch, Voltaren Gel. Pennsaid. Low systemic absorption minimizes NSAID ADRs

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3
Q

What is the generic name of Trexall?

A

Methotrexate (Non-Biologic DMARD) - RA

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4
Q

What does DMARD stand for?

A

Disease-Modifying Antirheumatic Drugs

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5
Q

What is the generic name of Arava?

A

Leflunomide (Non-Biologic DMARD) - RA

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6
Q

What is the generic name of Plaquenil?

A

Hydroxychloroquine (Non-Biologic DMARD) - RA

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7
Q

What is the generic name of Azulfidine?

A

Sulfasalazine (Non-Biologic DMARD) - RA

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8
Q

What is the generic name of Minocin?

A

Minocycline (Non-Biologic DMARD) - RA (not FDA-approved)

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9
Q

What is considered the DOC for RA?

A

Trexall (Methotrexate)

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10
Q

How often is Methotrexate dosed?

A

WEEKLY!!!

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11
Q

What supplementation do you need while on Methotrexate therapy?

A

Folic acid

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12
Q

What are the contraindications for Methotrexate use?

A

Liver disease/EtOH. Immunodeficiency. Pleural or peritoneal effusions. Leukopenia. Thrombocytopenia. Pre-existing blood disorders. CrCl < 40. Pregnancy and Lactation

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13
Q

What is Arava (Leflunomide) indicated for?

A

RA/JRA only. As effective as MTX, but $$$$

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14
Q

How is Arava (Leflunomide) dosed?

A

3 day loading dose, then DAILY maintenance

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15
Q

What are the contraindications for Azulfidine (Sulfasalazine)?

A

Sulfa allergy. Salicylate allergy. GI obstruction

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16
Q

What are some classes of medications that fall under the Biologic DMARDs?

A

TNF-a Inhibitors, T Cell Inhibitor, B Cell Modifier, IL-6 Inhibitor, Janus Kinase Inhibitor

17
Q

What is the generic name of Enbrel?

A

Etanercept (TNF-a inhibitor) - RA, can be used alone or with MTX

18
Q

What is the generic name of Humira?

A

Adalimumab (TNF-a inhibitor) - RA, can be used alone or with other DMARDs

19
Q

What is the generic name of Remicade?

A

Infliximab (TNF-a inhibitor) - RA, can be used alone or with MTX

20
Q

What are the BBWs for TNF-a inhibitors?

A

Contraindicated with any infection, Tuberculosis

21
Q

What is the generic name of Rituxan?

A

Rituximab (B-cell modifier) - RA, LAST LINE

22
Q

What are the BBWs for Rituxan (Rituximab)?

A

Fatal infusion reactions. Tumor lysis syndrome. Severe mucocutaneous reactions. Progressive multifocal leukoencephalopathy

23
Q

What type of screening is recommended in all patients being considered for biologic DMARD therapy?

A

TB screening

24
Q

Which DMARD is also an antimalarial drug?

A

Hydroxychloroquine

25
Q

What are the potential ADRs with MTX?

A

Bone marrow suppression, GI upset, pulmonary fibrosis

26
Q

What is a potentially serious side effect of Hydroxychloroquine?

A

Retinal toxicity

Board Study Topics (38 decks)

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