Zoonotic Gm - Rods

Question 1

Zoonotic Gm- Rods Facts

Answer 1

Uncommon in US
Little or no transmission between humans
Fastidious, multiply in phagocytes
highly virulent
Usually treat with aminoglycosides

Question 2

Zoonotic gm-Rods to know (5)

Answer 2

Brucella
Patella multocida
Franciscella tularensis
Yersinia pestis
Pseudomonas aeruginosa

Question 3

Brucella

• habitat
• disease
• culture
• prevention
• trx

Answer 3

Bruce Farms

• Unpastuerized dairy, Livestock/dog/goat/human, transmitted by contract, inhalation of aerosols, bad milk/meat
• reticulo endothelial dage, can spread systemically, possible osteomyelitis-primary is undulant fever and chills
• brucella agar
• test and immunize cattle/cook food fully/pastueize milk
• doxy and rifampin

Question 4

Franciscella tularensis

• habitat
• disease
• culture
• trx

Answer 4

Francis the rabbit

• -wild animals esp rabbit, transmissions with bite (animal or dermacentor tick)
• ulcer, enter macrophages, caseating necrosis at lymph, regional lymphadenopathy, septicemia
• immunoflouresce/agglutination
• streptomycin

Question 5

Pasturella multocida

• habitat
• disease
• culture
• trx

Answer 5

Louis Pasteur’s Lab

• oral flora of many animals-dog or cat bite
• cellulitis that can spread to osteomyelitis, possibly lymphadenopathy (if have predisposing liver disease/COPD)-snuffles (deadly) in rabbit
• culture in blood agar with elevated CO2, catalase positive, oxidase positive, capsule, safety pin staining
• amoxycilin/penicilin and beta lactase inhibitors to prevent resistance

Question 6

Pseudomonas aeruginosa

• habitat
• virulence
• disease
• culture
• trx
• special

Answer 6

The Suitors of Pseudo Mona (probably also in enteric)

• widespread in soil, water veg, biofilms (hot tub and lungs)
• extracellular poly sac, pilli, PLS, extracelluar enzymes that degrade ECM, Exotoxin A-Type 3 secretory system
• hot tubfolliculitis/otitis extern, infect any tissue organ, septicemia, CF problems due to biofilm
• non fastidious, siderospobes that tinge culture green, grape smell, slightly curved and polar flagella
• Piperacillin and bacterium, fluroquionilones
• community is usually contaminated water (need serious autoimmune weakness for bad infection), nosocomial is burn victimsnd intubated patients

Question 7

Yersinia pestis

• habitat
• virulence
• disease
• culture
• trx

Answer 7

Yershin’s Pets-Rodent capsule

• pathogen of small rodents in US SW, transmitted through flea bite (clot-regurgitation of previous meal system), can be aerosolized
• phagocytic paralysis, Fe acquisition, capsule, Yersinia outer protein-cause macrophage and neutrophil destruction-allow quick spread-type 3 secretion
• bubonic/pneumonic plague, bubos (lymphadenopathy), sepsis, bleeding lesions, endotoxins cause necrosis of tissues, exotoxins too, peripheral gangrine
• MacConkey and blood agar-looks like safety pin, NAAT, resistant to cold
• Streptomycin/aminoclycoside and tetracycline, also there is a killed vaccine