Enterobacteriae GM - Rods General

Question 1

Enterobacteriaceae general facts

• structure
• living condition
• transmission
• virullence
• ID
• Trx

Answer 1

short thick GM- rods with peritricous flagella (except Shigella)

Facultative anaerobes

Fecal/oral transmission-(feces, finges, flies, food/water)

Endotoxin, exotoxin, adhesive pilli, multiply in/invade cells, pathogenic islands, plasmids, phage genetics

Oxidase negative, 3 antigens (H-flagella, O-LPS, K-capsule)

Usually gram negative b-lacams (amino penicillin, cephtriaxine, ahminoglycosides, fluoroquinolones)

Question 2

Enterobacteriaceae important genera
6 with 7-9 together

also what main disease they cause

Answer 2

Salmonella (tyhoid, enteric fevers), Shigella (dysentery), Yersinia (black death), Escherichia water/bloody diarrhea, UTI, bactermia/meningitis), Proteus (UTI), Klebsiella, enterobacter, serrate

Question 3

Vibriocholerae-Vibrio cholerae

• structure
• natural habitat
• transmission
• ID

Answer 3

-Curved GM- rods with polar flagella
-fresh and sea water
-Endotoxin, exotoxin, adhesive pilli, multiply in/invade cells, pathogenic islands, plasmids, phage genetics
-oxidase +
Usually gram negative b-lacams (amino penicillin, cephtriaxine, ahminoglycosides, fluoroquinolones)

Question 4

which are the two curved G-rods

-what is main type of Sx caused

Answer 4

campylobacter (enteric and other infections) and helicobacter (peptic ulcer)

Question 5

1st type of enteric infection

• sx
• location
• virulence
• disease
• pathogens

Answer 5

Noninflammatory

• water diarrhea with no fever/WBC in feces
• small intestine
• adhesions, enterotoxins/exotoxins
• Exotoxins making solute going into lumen and H2O follows
• V. cholera and E coli ETEC

Question 6

2nd type of enteric infection

• sx
• location
• virulence
• disease
• pathogens

Answer 6

Inflammatory

• (potentially blood) diarrhea, fever, neutrophils in feces
• colon/rectum/SI
• adhesions, invasins, cytotoxins
• cell invasion and killing (type 3), local infmallatory mediators produced, systemic disease by exotoxin
• Shigella, Salmonella, EHEC, camplybacter

Question 7

3rd type of enteric infection

Answer 7

Penetrating

• early GI Sx, late enteric fever (systemic febrile illness due to bacteremia), mononuclear WBC in feces
• intestine, local lymph nodes, bloodstream
• adhesins, invasion, kill phagocytes
• Survival in or paralysis of phagocytes
• yersinia-to lymphatics, Salmonella-typhoidal/systemic