Respiratory GM - Rods

Question 1

Haemophilus Influenzae

• habitat
• Virulence
• Infections
• ID
• Trx

Answer 1

Phyllis’s Chocolate Covered Cherries

• huamns only, URT mucous membranes, resp droplets
• Some encapsulated, IgA protease, extract iron
• URI/Meningitis/Bactermia-via encapsulated, acute epiglottitis/invasion of resporiatry epi in children; local spread from pharynx to sinuses, middle ear, lungs in normalpople
• Slder pleomorphic gram neg coccipbacillary on chocolate agar that needs NAD and Hemin
• Diptheria toxoid in under 2 years old, ceftriaone in all else

Question 2

Bordetella pertussis

• habitat
• Virulence
• Infections
• ID
• Trx

Answer 2

Board and Care

• humans only-spread by resp droplets, 2wks incubation where just lacrimation and conjunctivas
• trachael cytotoxin-activates IL1 and kills tracheal ciliated epi that would normally clear bacteria, adenyl cyclase toxin-calmodlin-activated cyclase, raise cAMP to impair neutrophils and induces apoptosis in macrophages, pertussis toxin (ADP ribosylates Gi protein-impairs leukocyte chemotaxis)….Filatmoous hemagglutin adehion-binds to cellular integrins, fimbrae that udnregous phase variation, BrkA-reduces sensitivity to complement
• Whooping cough-running nose, malaise, dry cough–cyanisis, vomiting CNS damage, pnumotoroxax, hernia, penumoia-inuslin secretion up stops at 100 days
• Blood agar and starch/charcoal (kill competitors)
• macrolides, aceullar vaccine-DTaP

Question 3

Respiratory Gm- Rods to know

Answer 3

haemophilus influenza
Bordatella pertussis
Haemaphilius ducreyi
Legionella pneumophila

Question 4

Haemaphilus ducreyi (3)

Answer 4

STI that causes chancroid

• looks like school of fish
• skin to lymph

Question 5

Legionella pneumonphilia

• habitat
• Virulence
• Infections
• ID
• Trx

Answer 5

S.S. Cysteine Joins the Legion

• environemtnal water, amoeba, macrophages (where replicate)
• multiply in phagosome in macrophages by blocking fusion of phagosome and lysosome
• Legionnaries-developed atypical pneumonia-diahhrea, near Sx, low salt, high fevers–Pontiac fever-no pneumonia-fever and malaise-self limited
• need buffered charcoal yeast agar in present elf iron and cystine and antibiotics
• legionella-Fluroquionolones>macrolides