DNA synthesis Inhibitors

Question 1

Class I DNA Synthesis Inhibitors

Answer 1

Antifolaxe drugs

-sulonamide and trimethoprim

Question 2

Sulfonamide

• mechansim
• names + uses
• Side FX

Answer 2

PABA analog that inhibits Dihydropteroate synthase
Bacteriostatic @ singly, bactericidal @ DHFR inhibitor

Sulfa/sulfi drugs-usually UTI but sulfasalazine is for IBD

precipitate in urine, cross allergenic, fever, rash, NVD

Question 3

Tripemhoprim

• mech
• use

Answer 3

Inhibits DHFR (DHF to THF) with specify to bacterial

Acute UTI

Question 4

Bacterium

Answer 4

wide variety use-shigella, salmonella, UTI, prostates, non-TB mycobacteria

MSSA, MRSA, respiratory tract infections (Haemophilis, Klebisiella)

Gram - sepsis including MDR (enterobacter and serratia)

Question 5

Class 2

• mech
• how know drug is in this class
• use

Answer 5

-DNA Gyrase (prevents release of supercoiled DNA)/Topo IV (can’t separate replicated DNA @ cell division)inhibitor-block bacterial DNA synthesis…allow cut but not reseal

flox or just ox

bactericidal vs gram- (gyrase) and gm + (topo IV)

Question 6

Class 2 DNA Synthesis Inhibitors
-major division + names (general)
-clinical uses (of major one and which are resp)
Side effects

Answer 6

-Great Gm- + moderate Gm+- (Cipro and all others except MG…see below)
vs Improved Gm+ (broad spectrum) Gemifoloxacin and mooxifloxacin

• Cipro best for Gm-, Anthrax, MDR UTI, Diarrhea (Shigella, Salmonella, ETEC, Camplylocater), soft tissue/bone/joint/respiratry infections
• -respitory=levofloxacin, gemifloxacin and moxifoxacin

-Rare, NVD, reversible arthopathy, DAMAGE GROWING CARTILAGE