Wu

Question 1

Only type _______ has subtypes

Answer 1

A

Question 2

Subtype classification based on

Answer 2

Hemagluttin and neuramindase

Question 3

Gradual changes of hemaglutin and neuramindase. Accumulation of point mutations. Types A and B. Epidemics

Answer 3

Drift

Question 4

Sudden changes of hemaglutin and neuramindase. Reassortment of genomic RNA segments. Type A. Pandemics

Answer 4

Shift

Question 5

Alpha 2,6 linked Sialic acids

Answer 5

Human flu virus

Question 6

Alpha 2,3 linked Sialic acids

Answer 6

Avian flu virus

Question 7

Trachea bronchial epithelium type 1 pneumocytes

Answer 7

Human flu virus, alpha 2,6

Question 8

Distal bronchiole epithelium, type 2 pneumocytes

Answer 8

Avian flu virus, alpha 2,3 linked

Question 9

__________ in cleavage site. Extracellular cleavage only. Viral replication in respiratory tracts

Answer 9

Single basic AA

Question 10

____ in cleavage site. Intracellular cleavage. Systemic viral replication

Answer 10

Multiple basic AAs

Question 11

No ________ with influenza

Answer 11

Viremia

Question 12

M2 inhibitors, inhibiting viral uncoating and replication. Risk of resistant mutants

Answer 12

Amantadine and rimantadine

Question 13

Neuramindase inhibitor. Reduce risk of pneumonia. Resistance uncommon

Answer 13

Oseltamivir and zanamivir

Question 14

Neutralizing antibodies directed against _______ to block infection

Answer 14

Hemaglutin

Question 15

Directed against internal (nucleoprotein, nuclear matrix protein) or surface glycoproteins. May cross rx to different subtypes

Answer 15

Cytotoxic t lymphocytes

Question 16

Based on cross reactivity and sequence similarity of nuclear matrix protein and nucleoprotein

Answer 16

Types A, B, and C