Salisbury2 Flashcards

1
Q

Need to be given with anti-inflammatory therapy (corticosteroids, Leukotriene inhibitors)

A

LABA

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2
Q

Development of airway tolerance to _____ as a result of chronic use has been a problem, but ___ administration may prevent tolerance by upregulating these receptors

A

Beta2

Glucocorticoids

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3
Q

Antagonize Ach at cholinergic receptors. Reduce Ach-mediated increases in __________

A

Muscarinic antagonists.

cAMP

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4
Q

Causes bronchial smooth muscle relaxation and inhibits mucus secretions

A

Muscarinic antagonists

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5
Q

Ipratropium, tiotropium

A

Muscarinic antagonist

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6
Q

FDA indicated for COPD

A

Muscarinic antagonists

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7
Q

Ipratropium is used for

A

Nasal discharge

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8
Q

Has an unpleasant bitter taste

A

Muscarinic antagonists

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9
Q

Bronchodilator and anti-inflammatory activity

A

Methylxanthines

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10
Q

Inhibits phosphodiesterases, adenosine receptor antagonist, anti-inflammatory, diaphragmatic muscle contraction

A

Theophylline

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11
Q

FDA indicated for asthma and COPD. Used as an adjunct in pts not controlled with steroids and beta-receptor agonists.

A

Theophylline

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12
Q

Used to treat apnea in preterm infants

A

Caffeine

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13
Q

For acute severe asthma exacerbations theophylline given

A

IV

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14
Q

Low therapeutic index. Toxicity dose dependent

A

Theophylline

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15
Q

Childhood, barbecued meat, smoking, ethanol, barbiturates

A

Increase theophylline clearance

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16
Q

CYP inhibition, CHF, liver disease, pneumonia, viral infection, vaccination, high carb diet, old age

A

Decrease theophylline clearance

17
Q

Nausea, vomiting, H/A, restlessness

A

Low level toxicity

18
Q

Cardiac arrhythmias and seizures

A

High level toxicity

19
Q

Beclomethasone, triamcinolone acetate, budesonide, flunisolide, fluticasone propionate

A

Corticosteroids

20
Q

Anti-inflammatory that acts via glucocorticoid receptor

A

Corticosteroids

21
Q

Front line therapy for persistent asthma, but much less effective in COPD

A

Inhaled corticosteroids

22
Q

Causes dysphonia

A

Inhaled corticosteroids

23
Q

Not first line, but FDA indicated for asthma

A

Leukotriene inhibitors

24
Q

Zafirlukast and montelukast

A

Leukotriene inhibitors

25
Q

Antagonists of Leukotriene receptor (LT1). Blocks actions of cysteinyl leukotrienes (LTC4, LTD4, LTE4). Inhibiting bronchoconstriction and airway inflammation

A

Leukotriene inhibitors

26
Q

Not for acute asthma attack

A

LABA