Salisbury2

Question 1

Need to be given with anti-inflammatory therapy (corticosteroids, Leukotriene inhibitors)

Answer 1

LABA

Question 2

Development of airway tolerance to _____ as a result of chronic use has been a problem, but ___ administration may prevent tolerance by upregulating these receptors

Answer 2

Beta2

Glucocorticoids

Question 3

Antagonize Ach at cholinergic receptors. Reduce Ach-mediated increases in __________

Answer 3

Muscarinic antagonists.

cAMP

Question 4

Causes bronchial smooth muscle relaxation and inhibits mucus secretions

Answer 4

Muscarinic antagonists

Question 5

Ipratropium, tiotropium

Answer 5

Muscarinic antagonist

Question 6

FDA indicated for COPD

Answer 6

Muscarinic antagonists

Question 7

Ipratropium is used for

Answer 7

Nasal discharge

Question 8

Has an unpleasant bitter taste

Answer 8

Muscarinic antagonists

Question 9

Bronchodilator and anti-inflammatory activity

Answer 9

Methylxanthines

Question 10

Inhibits phosphodiesterases, adenosine receptor antagonist, anti-inflammatory, diaphragmatic muscle contraction

Answer 10

Theophylline

Question 11

FDA indicated for asthma and COPD. Used as an adjunct in pts not controlled with steroids and beta-receptor agonists.

Answer 11

Theophylline

Question 12

Used to treat apnea in preterm infants

Answer 12

Caffeine

Question 13

For acute severe asthma exacerbations theophylline given

Answer 13

IV

Question 14

Low therapeutic index. Toxicity dose dependent

Answer 14

Theophylline

Question 15

Childhood, barbecued meat, smoking, ethanol, barbiturates

Answer 15

Increase theophylline clearance

Question 16

CYP inhibition, CHF, liver disease, pneumonia, viral infection, vaccination, high carb diet, old age

Answer 16

Decrease theophylline clearance

Question 17

Nausea, vomiting, H/A, restlessness

Answer 17

Low level toxicity

Question 18

Cardiac arrhythmias and seizures

Answer 18

High level toxicity

Question 19

Beclomethasone, triamcinolone acetate, budesonide, flunisolide, fluticasone propionate

Answer 19

Corticosteroids

Question 20

Anti-inflammatory that acts via glucocorticoid receptor

Answer 20

Corticosteroids

Question 21

Front line therapy for persistent asthma, but much less effective in COPD

Answer 21

Inhaled corticosteroids

Question 22

Causes dysphonia

Answer 22

Inhaled corticosteroids

Question 23

Not first line, but FDA indicated for asthma

Answer 23

Leukotriene inhibitors

Question 24

Zafirlukast and montelukast

Answer 24

Leukotriene inhibitors

Question 25

Antagonists of Leukotriene receptor (LT1). Blocks actions of cysteinyl leukotrienes (LTC4, LTD4, LTE4). Inhibiting bronchoconstriction and airway inflammation

Answer 25

Leukotriene inhibitors

Question 26

Not for acute asthma attack

Answer 26

LABA