Salisbury2 Flashcards
Need to be given with anti-inflammatory therapy (corticosteroids, Leukotriene inhibitors)
LABA
Development of airway tolerance to _____ as a result of chronic use has been a problem, but ___ administration may prevent tolerance by upregulating these receptors
Beta2
Glucocorticoids
Antagonize Ach at cholinergic receptors. Reduce Ach-mediated increases in __________
Muscarinic antagonists.
cAMP
Causes bronchial smooth muscle relaxation and inhibits mucus secretions
Muscarinic antagonists
Ipratropium, tiotropium
Muscarinic antagonist
FDA indicated for COPD
Muscarinic antagonists
Ipratropium is used for
Nasal discharge
Has an unpleasant bitter taste
Muscarinic antagonists
Bronchodilator and anti-inflammatory activity
Methylxanthines
Inhibits phosphodiesterases, adenosine receptor antagonist, anti-inflammatory, diaphragmatic muscle contraction
Theophylline
FDA indicated for asthma and COPD. Used as an adjunct in pts not controlled with steroids and beta-receptor agonists.
Theophylline
Used to treat apnea in preterm infants
Caffeine
For acute severe asthma exacerbations theophylline given
IV
Low therapeutic index. Toxicity dose dependent
Theophylline
Childhood, barbecued meat, smoking, ethanol, barbiturates
Increase theophylline clearance