Salisbury3

Question 1

Montelukast can be used for

Answer 1

Allergic rhinitis

Question 2

Inhibits 5-Lipoxygenase the rate limiting enzyme in Leukotriene biosynthesis

Answer 2

Zileuton

Question 3

Oral. Metabolized by CYPs

Answer 3

Leukotriene inhibitors

Question 4

Associated with hepatotoxicity

Answer 4

All Leukotriene inhibitors

Question 5

Hepatotoxicity highest with ________ and lowest with ________

Answer 5

Zileuton

Montelukast

Question 6

Inhibits metabolism of warfarin

Answer 6

Zafirlukast

Question 7

Does not inhibit hepatic CYPs

Answer 7

Montelukast

Question 8

Inhibits microsomal P450s, decreasing metabolism of warfarin and theophylline. Can cause fever and chills

Answer 8

Zileuton

Question 9

Cromolyn and nedocromil

Answer 9

Mast cell stabilizers

Question 10

Humanized monoclonal antibody against IgE. Inhibits IgE binding to mast cells. Reserved for severe asthma not controlled by corticosteroids. Subcutaenous

Answer 10

Omalizumab

Question 11

Can cause anaphylaxis

Answer 11

Omalizumab

Question 12

Prolastin, aralast

Answer 12

Alpha-1 proteinase inhibitors

Question 13

Constipation and addictive potential. Respiratory depression

Answer 13

Anti-tussives

Question 14

Centrally active NMDA receptor antagonist. Does not bind opioid receptors. D isomer of codeine analog methorphan

Answer 14

Dextromethorphan

Question 15

Suppresses cough through peripherally targeting cough receptors of vagal afferents. Can cause dizziness

Answer 15

Benzonatate

Question 16

Irritation of gastric mucosa and stimulates respiratory tract secretions. Expectorant. Causes vomiting

Answer 16

Guaifenesin

Question 17

Cleaves disulfide bonds (via its sulfhydryl group) in mucus glycoproteins allowing the mucus to thin

Answer 17

N-acetylcysteine

Question 18

Indicated for acetaminophen overdose. Adjunct for cystic fibrosis with pulmonary complications

Answer 18

N-acetylcysteine

Question 19

DNAse that cleaves extracellular DNA in mucus allowing it to thin. Adjunct for cystic fibrosis

Answer 19

Dornase alpha

Question 20

Oxymetazoline, pseudo ephedrine, phenylephrine

Answer 20

Adrenergic agonists

Question 21

Selective alpha 1 receptor agonist

Answer 21

Phenylephrine

Question 22

Alpha receptor agonist

Answer 22

Oxymetazoline

Question 23

Alpha and beta agonist

Answer 23

Pseudoephedrine

Question 24

Used as nasal decongestants

Answer 24

Adrenergic agonists

Question 25

Can cause rebound nasal congestion. Pts with uncontrolled HTN or IHD should avoid

Answer 25

Adrenergic agonists

Question 26

Potential alternative to medium-dose inhaled steriods for prophylaxis of mild persistent asthma

Answer 26

Leukotriene inhibitors