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Exam 10 > Salisbury > Flashcards

Salisbury Flashcards

1
Q

Increased bronchospastic mediators (histamine, Leukotriene D4, and prostaglandin D4)

A

Asthma

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2
Q

Increased #s inflammatory cells (neutrophils, macrophages, CTLs)

A

COPD

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3
Q

Deficiency in alpha1-proteinase inhibitor

A

COPD

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4
Q

Nasal epithelium inflammation. IgE mediated activation of mast cells and basophils. Histamine, prostaglandins, and leukotrienes mediators of inflammation

A

Allergic rhinitis

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5
Q

Oral dose much higher relative to inhaled dose for same effect. Ratio?

A

20:1

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6
Q

Stimulate beta-2 adrenergic receptors > ^ cAMP > activating PKA > bronchial smooth muscle relaxation

A

Adrenergic agonist

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7
Q

Quick relief during asthma attack. Onset of action 1-5 mins. Duration of action 4-6 hrs

A

SABA

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8
Q

Asthma prophylaxis and COPD. Duration of action longer than 12 hrs

A

LABA

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9
Q

Salmeterol and formoterol

A

LABA

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10
Q

Longer duration of action and indicated for COPD

A

Indacaterol

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11
Q

Extended lipophilic side chain on _______ leads to longer duration of action than albuterol

A

LABA

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12
Q

Albuterol, terbutaline, pirbuterol, and metaproterenol

A

SABA

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13
Q

Not effective for COPD

A

SABA

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14
Q

Not to be used several times a day and overuse indicates need for more anti-inflammatory therapy

A

SABA

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15
Q

Tolerance could be due to beta2-receptor down regulation

A

SABA

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16
Q

Causes tremor. More likely with higher doses

A

SABA

17
Q

Potent bronchodilator. Inhaled and oral. Used during acute asthma attack. Inhalation/sublingual forms no longer available in US. Non-selective SABA

A

Isoproterenol

18
Q

Non-selective alpha and beta agonist. Potent bronchodilator. Used for acute asthma attack

A

Epi

19
Q

Salmeterol, formoterol, and Indacaterol

A

LABA

20
Q

Effective for asthma and COPD

A

LABA

21
Q

Increased inflammatory cells (mast cells, eosinophils, Th2 cells)

A

Asthma

Exam 10 (15 decks)

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