Miller Flashcards
Recycled by type 2 pneumocyte. Deficiency compatible with life. Acts as an opsonin
SP-A
Fuss genie. Enhances spread and stability of surfactant layer. Required for extra-uterine life
SP-B
Most hydrophobic. Must be activated by SP-B
SP-C
Recruits phospholipids to lipid layer
SP-C
Deficiency is AD, compatible with life, but pts will develop interstital pneumonitis and emphysema later
SP-C
Largest. Not involved in stabilizing/recycling surfactant
SP-d
Innate immunity. Cruciform.
SP-D
Steroids(stress, estrogen, thyroid hormone ___________ surfactant production
Increase
High levels of insulin ______ surfactant production
Decrease
Increases surfactant production, decreases alveolar division and bronchial length
Betamethasone
16-24 wks
Canalicular stage
Capillary bed expands and thins
Canalicular stage
Thinning and surfactant production accelerated by
Glucocorticoids
24-38 wks
Saccular stage
Cell proliferation decreases > Decreased mesenchymal tissue
Saccular stage
Increased type 2 cell maturation
Saccular stage
36 wks to 2/3 yrs after birth
Alveolar stage
Marked increased in epithelial cells
Alveolar stage
Changes in pulmonary vasculature (decreased smooth muscle, decreased PVR)
Alveolar stage
Bouquet. Must abundant
SP-A
