Miller

Question 1

Recycled by type 2 pneumocyte. Deficiency compatible with life. Acts as an opsonin

Answer 1

SP-A

Question 2

Fuss genie. Enhances spread and stability of surfactant layer. Required for extra-uterine life

Answer 2

SP-B

Question 3

Most hydrophobic. Must be activated by SP-B

Answer 3

SP-C

Question 4

Recruits phospholipids to lipid layer

Answer 4

SP-C

Question 5

Deficiency is AD, compatible with life, but pts will develop interstital pneumonitis and emphysema later

Answer 5

SP-C

Question 6

Largest. Not involved in stabilizing/recycling surfactant

Answer 6

SP-d

Question 7

Innate immunity. Cruciform.

Answer 7

SP-D

Question 8

Steroids(stress, estrogen, thyroid hormone ___________ surfactant production

Answer 8

Increase

Question 9

High levels of insulin ______ surfactant production

Answer 9

Decrease

Question 10

Increases surfactant production, decreases alveolar division and bronchial length

Answer 10

Betamethasone

Question 11

16-24 wks

Answer 11

Canalicular stage

Question 12

Capillary bed expands and thins

Answer 12

Canalicular stage

Question 13

Thinning and surfactant production accelerated by

Answer 13

Glucocorticoids

Question 14

24-38 wks

Answer 14

Saccular stage

Question 15

Cell proliferation decreases > Decreased mesenchymal tissue

Answer 15

Saccular stage

Question 16

Increased type 2 cell maturation

Answer 16

Saccular stage

Question 17

36 wks to 2/3 yrs after birth

Answer 17

Alveolar stage

Question 18

Marked increased in epithelial cells

Answer 18

Alveolar stage

Question 19

Changes in pulmonary vasculature (decreased smooth muscle, decreased PVR)

Answer 19

Alveolar stage

Question 20

Bouquet. Must abundant

Answer 20

SP-A