Siegel Flashcards

1
Q

Almost always metastatic

A

Small cell carcinoma

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2
Q

Produces parathyroid related hormone

A

Squamous cell carcinoma

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3
Q

P53 mutations

A

Squamous cell carcinoma

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4
Q

CK5/6, P63

A

Squamous cell carcinoma

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5
Q

FGFR1 amplification (encodes for receptor tyrosine kinase)

A

Squamous cell carcinoma

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6
Q

Lepidic growth pattern

A

Adenocarcinoma in situ

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7
Q

Terminal bronchioloalveolar regions

A

Adenocarcinoma in situ

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8
Q

GOF in genes encoding for receptor tyrosine kinase

A

Adenocarcinoma

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9
Q

+ for synaptophysin, chromogranin, and CD56

A

Neuroendocrine tumors

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10
Q

MYC amplification

A

Small cell carcinoma

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11
Q

Salt and pepper chromatin pattern. Increased mitotic figures and necrosis

A

Small cell carcinoma

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12
Q

Azzopardi effect

A

Small cell carcinoma

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13
Q

Males = females. Palisading and organoid pattern. Typical vs atypical

A

Carcinoid

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14
Q

P53 mutation. 2-10 mitotic figures per high power field.

A

Atypical carcinoid

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15
Q

Coin lesion. Incidental. Peripheral

A

Hamartoma

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16
Q

Stroma like and epithelial components.

A

Hamartoma

17
Q

Young women of childbearing age. Spontaneous pneumothorax. Perivascular Epitheloid cell proliferation

A

Lymphangioleiomyomatosis

18
Q

Children/young adults. Peripheral. ALK (a aplastic lymphoma kinase) activation on 2p23

A

Inflammatory myofibroblastic tumor

19
Q

Lambert Eaton myasthenia syndrome

A

Small cell carcinoma

20
Q

Pancoast tumor causes

A

Horner’s syndrome ipsilateral

21
Q

Always visceral pleura. No effusion

A

Solitary fibrous tumor

22
Q

CD34 + and keratin -

A

solitary fibrous tumor

23
Q

Calretinin, CK5/6

A

Malignant mesothelioma

24
Q

Long microvilli

A

Malignant mesothelioma

25
Q

Absence of long microvilli

A

Adenocarcinoma

26
Q

Adenocarcinoma mutation in non-smokers

A

EGFR