Siegel Flashcards
Almost always metastatic
Small cell carcinoma
Produces parathyroid related hormone
Squamous cell carcinoma
P53 mutations
Squamous cell carcinoma
CK5/6, P63
Squamous cell carcinoma
FGFR1 amplification (encodes for receptor tyrosine kinase)
Squamous cell carcinoma
Lepidic growth pattern
Adenocarcinoma in situ
Terminal bronchioloalveolar regions
Adenocarcinoma in situ
GOF in genes encoding for receptor tyrosine kinase
Adenocarcinoma
+ for synaptophysin, chromogranin, and CD56
Neuroendocrine tumors
MYC amplification
Small cell carcinoma
Salt and pepper chromatin pattern. Increased mitotic figures and necrosis
Small cell carcinoma
Azzopardi effect
Small cell carcinoma
Males = females. Palisading and organoid pattern. Typical vs atypical
Carcinoid
P53 mutation. 2-10 mitotic figures per high power field.
Atypical carcinoid
Coin lesion. Incidental. Peripheral
Hamartoma
Stroma like and epithelial components.
Hamartoma
Young women of childbearing age. Spontaneous pneumothorax. Perivascular Epitheloid cell proliferation
Lymphangioleiomyomatosis
Children/young adults. Peripheral. ALK (a aplastic lymphoma kinase) activation on 2p23
Inflammatory myofibroblastic tumor
Lambert Eaton myasthenia syndrome
Small cell carcinoma
Pancoast tumor causes
Horner’s syndrome ipsilateral
Always visceral pleura. No effusion
Solitary fibrous tumor
CD34 + and keratin -
solitary fibrous tumor
Calretinin, CK5/6
Malignant mesothelioma
Long microvilli
Malignant mesothelioma
Absence of long microvilli
Adenocarcinoma
Adenocarcinoma mutation in non-smokers
EGFR
