Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Exam 10 > Restrictive1 > Flashcards

Restrictive1 Flashcards

1
Q

In IPF type 1 alveolar cells release

A

TGF-beta1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

TGFbeta1 negatively regulates ________ in IPF

A

Telomerase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Mutations in TERT/TERC

A

IPF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Cobblestone surface. Sub pleural lesions in lower lobe

A

IPF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Temporal heterogeneity

A

IPF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Has cellular or fibrosing pattern

A

Nonspecific interstitial pneumonia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Fibrosing pattern

A

Worse prognosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

No fibroblastic foci or honeycomb lung

A

NSIP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Good prognosis, can be treated with steriods

A

NSIP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Response to infectious or inflammatory injury. Masson bodies

A

Cryptogenic organizing pneumonia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Polyploid plugs of loose CT w/o temporal heterogeneity

A

COP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Normal lung architecture > no interstitial fibrosis or honeycomb lung

A

COP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Treat with steroid therapy for 6 months

A

COP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Carbon particles in lung tissues. Accumulation of carbon pigment in macrophages along pulmonary lymphatics and LNs

A

Anthracosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Coal macules w/ ___________

Coal nodules with _______

A

Simple CWP
Carbon laden macrophages
Collagen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Upper lobes and upper zones of lower lobes

A

Simple CWP

17
Q

Multiple blackened scars of fibrosis made of dense collagen, carbon pigment, and necrotic centers

A

Complicated CWP

18
Q

Pneumoconiosis and rheumatoid arthritis.

Rapidly developing lung nodules

A

Caplan syndrome

19
Q

Crystalline or amorphous form

A

Silicosis

20
Q

_________ form causes more fibrosis (especially Quartz) in silicosis

A

Crystalline

21
Q

Activates macrophages causing release of factors TNF, IL1, O2 derived free radicals

A

Silica

22
Q

Pale/dark nodules in upper lung zones early on

A

Silicosis

23
Q

Later nodules coalesce to form hard, collagenous scars surrounded by concentric layers of hyalinized collagen and a dense eggshell calcification capsule

A

Silicosis

24
Q

Increased susceptibility to TB

A

Silicosis

25
Q

Initial injury at bifurcations of small airways where fibers penetrate macrophages and activate them

A

Asbestos

26
Q

Act as tumor promoters by free radical production. Carcinogens bind to fibers

A

Asbestos

27
Q

Fibrosis around respiratory bronchioles, alveolar ducts, sacs, and alveoli

A

Asbestos

28
Q

Begins in lower lobes

A

Asbestos

29
Q

Found on diaphragm usually. Do not contain asbestos bodies

A

Pleural plaques

30
Q

Systemic. Dx of exclusion

A

Sarcoidosis

31
Q

Increased prevalence in women. Especially African Americans in SE USA

A

Sarcoidosis

32
Q

HLA subtypes in sarcoidosis

A

A1 and B8

33
Q

Repeated cycles of epithelial activation and injury. Fibroblastic foci

A

Idiopathic pulmonary fibrosis (UIP)

Exam 10 (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions