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Exam 10 > Histamine > Flashcards

Histamine Flashcards

1
Q

Histamine acted on by diamine oxidase forms

A

Imidazole acetic acid

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2
Q

Histamine acted on by histamine n-methyltransferase forms

A

N-methylhistamine

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3
Q

Receptor found on smooth muscle, endothelium, and brain

A

H1

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4
Q

Receptor found on gastric mucosa, cardiac muscle, mast cells, brain

A

H2

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5
Q

Gq receptor. Increase IP3 and DAG

A

H1

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6
Q

Gs receptor. Increases cAMP

A

H2

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7
Q

Partially selective agonist 2-methyl-histamine

A

H1

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8
Q

Partially selective antagonist chlorpheniramine

A

H1

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9
Q

Partially selective agonist dimaprit

A

H2

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10
Q

Partially selective antagonist ranitidine

A

H2

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11
Q

Chlorpheniramine, Diphenhydramine, Hydroxyzine, Promethazine

A

Histamine antagonist 1st gen

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12
Q

Cetirizine, Loratadine, Fexofenadine

A

Histamine antagonist 2nd gen

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13
Q

Diphenhydramine, Promethazine have

A

CNS sedation and antimuscarinic properties

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14
Q

Cetirizine has

A

CNS sedation

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15
Q

Metabolized by cyp3A4.

Important in drugs that inhibit CYP3A4, such as ketoconazole

A

2nd gen (Loratadine)

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16
Q

Strongest muscarinic blocking effects

Fights motion sickness

A

Promethazine

17
Q

Seen in H1 antagonist poisoning

A

CNS excitation

18
Q

Decrease gastric acid secretion from parietal cells

A

H2 antagonists

19
Q

Have significant renal excretion so must lower dose in renal disease

A

H2 antagonists

20
Q

Significant drug interactions by inhibiting P450 and decreasing metabolism of other drugs

A

Cimetidine

21
Q

Beta-aminoethylimidazole

A

Histamine

Exam 10 (15 decks)

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