Wound healing tissue mediators Flashcards

1
Q

PDGF

A

(Platelet-derived growth facto)
Secreted by activated platelets and macrophages
Induce vascular remodeling and smooth muscle migration
Stimulates fibroblast growth for collagen synthesis

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2
Q

FGF

A

(Fibroblast growth factor)

Simulates angiogenesis

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3
Q

EGF

A

(Epidermal growth factor)

Stimulates cell growth via tyrosine kinase (EGFR/ErbB1)

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4
Q

TGF-b

A

Angiogenesis, fibrosis, cell cycle arrest

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5
Q

Metalloproteinases

A

Tissue remodeling

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6
Q

VEGF

A

(Vascular endothelial growth factor)

Stimulates angiogenesis

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