Wound healing tissue mediators Flashcards
1
Q
PDGF
A
(Platelet-derived growth facto)
Secreted by activated platelets and macrophages
Induce vascular remodeling and smooth muscle migration
Stimulates fibroblast growth for collagen synthesis
2
Q
FGF
A
(Fibroblast growth factor)
Simulates angiogenesis
3
Q
EGF
A
(Epidermal growth factor)
Stimulates cell growth via tyrosine kinase (EGFR/ErbB1)
4
Q
TGF-b
A
Angiogenesis, fibrosis, cell cycle arrest
5
Q
Metalloproteinases
A
Tissue remodeling
6
Q
VEGF
A
(Vascular endothelial growth factor)
Stimulates angiogenesis