Drug reactions (all systems here) Flashcards
Name the sulfa drugs
Sulfonamide antibiotics Sulfasalazine Probenecid Furosemide Acetazolamide Celecoxib Thiazides Sulfonylureas
– Fever, UTI, SJS, hemolytic anemia, thrombocytopenia, agranulocytosis, urticaria
Coronary vasospasm 3
Cocaine
Sumatriptan
Ergot alkaloids
Cutaneous flushing 5VANCE
Vancomycin Adenosine Niacin Ca CB Echinocandins
Dilated cardiomyopathy
Anthracyclines (doxorubicin, daunorubicin)
prevent with Dexrazoxane
Torsades de pointes
AntiArrhythmics (IA, III) AntiBiotics (macrolides) AntiCychotics (haloperidol) AntiDepressants (TCAs) AntiEmetics (ondansetron)
Adrenocortical insufficiency
HPA suppression secondary to glucocorticoid withdrawal
Hot flashes
Tamoxifen
Clomiphene
Hyperglycemia
Tacrolimus Protease inhibitors Niacin HCTZ Corticosteroids
Hypothyroidism
Lithium
Amiodarone
Sulfonamides
Acute cholestatic hepatitis (jaundice)
Erythromycin
Diarrhea
Acamprosate Acarbose Cholinesterase inhibitor (inc ACh, inc parasympathetics) Colchicine Erythromycin Ezetimibe Metformin Misoprostol Orlistat Pramlintine Quinidine SSRIs
Focal to massive hepatic necrosis
Halothane
Amanita phalloids (death cap mushrooms)
Valproid acid
Acetaminophen
Liver “HAVAc”
Hepatitis
Rifampin Isoniazid (anti TB, stops mycolic acid synthesis) Pyrazinamide Statis Fibrates
Pancreatitis
Didanosine Corticosteroids Alcohol Valproid acid Azathioprine Diuretics (furosemine, HCTZ)
“Drugs Causing a Violent Abdominal Distress”
Pill-induced esophagitis
Tetracyclines
Bisphosphonates
Potassium chloride
- Caustic effect minimized with upright posture and adequate water ingestion
Pseudomembranous colitis
Clindamycin
Ampicillin
Cephalosporin
- abx predispose to superinfections by resistant C diff
Agranulocytosis
Clozapine Carbamazepine Prophylthiouracil Methimazole Colchicine Ganciclovir
“Can Cause Pretty Major Collapse of Granulocytes”
Aplastic anemia
Carbamazepine Methimazole NSAIDs Benzene Chloramphenicol Propylthiouracil
“Can’t Make New Blood Cell Properly”
Direct Coombs-positive hemolytic anemia
Methyldopa
Penicillin
Gray baby syndrome
Chloramphenicol
Hemolysis in G6PD deficiency
Isoniazid Sulfonamides Dapsone Primaquine Aspirin Ibuprofen Nitrofurantoin
“Hemolysis IS D PAIN”
MegaloBLASTic anemia
Phenytoin
Methotraxate
Sulfa drugs
“Having a BLAST with PMS”
Thrombocytopenia
Heparin
Thrombotic complications
OCPs
Hormone replacement therapy
Fat redistribution
Protease inhibitors
Glucocorticoids
“Fat PiG”
Gingival hyperplasia
Phenytoin
Ca CB
Cyclosporine
Hyperuricemia (gout)
Pyrazinamide Thiazides Furosemide Niacin Cyclosporine
“Painful Tophi and Feet Need Care”
Myopathy
Fibrates Niacin Colchicine Hydroxychloroquine Interferon alpha Penicillamine Statins Glucocorticoids
Osteoporosis
Corticosteroids
Heparin
Photosensitivity
Sulfonamides
Amiodarone
Tetracyclines
5-FU
“STAT For Photo”
Rash (SJS)
Anti-epileptic drugs (Lamotrigine)
Allopurinol
Sulfa drugs
Penicillin
“Steven Johnson has epileptic allergy to sulfa drugs and penicillin”
SLE-like syndrome
Sulfa drugs Hydralazine Isoniazid Procainamide Phenytoin Etanercept
“Having lupus is SHIPPE”
Teeth discoloration
Tetracyclines
Tendonitis, tendon rupture and cartilage damage
Fluoroquinolones
Cinchonism
Quinine, quinidine
Parkinson-like syndrome
Antipsychotics
Reserpine
Metoclopramide
Seizures
Isoniazid (vit B6 def) Bupropion Imipenem/cilastatin Tramadol Enflurane
Tardive dyskinesia
Antipsychotics
Metoclopramide
Diabetes Insipidus
Lithium
Demeclocycline
Fanconi syndrome
Tenofovir
Ifosfamide
Hemorrhagic cystitis
Cyclophosphamide
Ifosfamide
Administer MESNA to prevent this
Interstitial nephritis
Methicillin
NSAIDs
Furosemide
SIADH
Carbamazepine
Cyclophosphamide
SSRIS
“Can’t Concentrate Serum Sodium”
Dry cough
ACE inhibitors
Pulmonary fibrosis
Methotraxate Nitrofurantoin Carmustine Bleomycin Bisulfan Amiodarone
“My Nose Cannot Breath Bad Air”
Antimuscarinic (multiorgan)
Atropine
TCAs
H1 blocker
Antipsychotics
Disulfiran-like rxn
Metronidazole Cephalosporins Griseofulvin Procabazine 1st gen sulfonylureas
Nephrotoxic/Ototoxic
Aminoglycosides
Vancomycin
Loop diuretics
Cisplatin (respond to amifostine)