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First Aid STEP 1 > Oncogenes (GOF) > Flashcards

Oncogenes (GOF) Flashcards

1
Q

ALK

A

Receptor tyrosine kinase –> lung adenocarcinoma

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2
Q

BCR-ABL

A

Tyrosine kinase –> CML, ALL

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3
Q

BCL-2

A

Antiapoptotic molecule (inhibits apoptosis by binding to APAF1) –> foliccular and diffuse large B cell lymphoma

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4
Q

BRAF

A

serine/threonine kinase –> Melanoma, non-Hodgkin lymphoma

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5
Q

c-KIT

A

Cytokine receptor –> Gastrointestinal stromal tumor (GIST)

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6
Q

c-MYC

A

Transcription factor –> Burkitt lymphoma

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7
Q

HER2/neu (c-erbB2)

A

Tyrosine kinase –> Breast and gastric carcinoma

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8
Q

JAK2

A

Tyrosine kinase –> Chronic myeloproliferative disorders

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9
Q

KRAS

A

GTPase –> Colon, lung and pancreatic cancer

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10
Q

MYCL1

A

Transcription factor –> Lung tumor

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11
Q

MYCN

A

Transcription factor –> Neuroblastoma

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12
Q

RET

A

Tyrosine kinase –> MEN 2A, 2B, medullary thyroid cancer

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First Aid STEP 1 (21 decks)

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