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First Aid STEP 1 > Tumor suppressor genes (LOF) > Flashcards

Tumor suppressor genes (LOF) Flashcards

1
Q

APC

A

Colorectal cancer (~ FAP)

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2
Q

BRCA1/BRCA2

A

Breast and ovarian –> DNA repair protein

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3
Q

CDKN2A

A

Melanoma, pancreatic cancer –> p16, blocks G1 to S phase

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4
Q

DCC

A

Colon cancer –> Deleted in Colon Cancer

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5
Q

DPC4/SMAD4

A

Pancreatic cancer –> Deleted in Pancreatic Cancer

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6
Q

MEN1

A

MEN1 = menin

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7
Q

NF1

A

Neurofibromatosis 1 –> Ras GTPase activating protein (neurofibromin)

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8
Q

NF2

A

Neutrofibromatosis 2 –> Merlin (shwannomin) protein

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9
Q

PTEN

A

Breast cancer, prostate cancer and endometrial cancer

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10
Q

Rb

A

Retinoblastoma, osteosarcoma –> Inhibits E2F; blocks G1->S

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11
Q

TP53

A

Most human cancers, Li-Fraumeni syndrome –> p53, activates p21, blocks G1->S

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12
Q

TSC1

A

Tuberous sclerosis –> Hamartin protein

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13
Q

TSC2

A

Tuberous sclerosis –> Tuberin protein

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14
Q

VHL

A

von Hipperl-Lindau disease, renal cell carcinoma –> inhibits hypoxia inducible factor 1a

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15
Q

WT1/WT2

A

Wilms Tumor (nephroblastoma)

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First Aid STEP 1 (21 decks)

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