Wound Healing, cihangir Flashcards
Which stage is the longest stage in wound healing?
Maturation
Which stage is the last stage in wound healing?
Maturation 4th stage
How long does maturtion stage lasts?
6-12 months
During which period is the serine proteases and matrix metalloproteases most active?
Maturation
What happens in kelloid scar and why does it over mature?
Bcz there’s an error in the maturation process specifically serine proteases and matrix matalloproteases is not working
How do you differentiate b/w Keloid scar and hypertrophic scar?
Keloid scar: exceeds the original wound limit; painful
Hypertrophic scar: develops within the borders of the wound; can form anywhere
Which layer in the skin has the highest tensile strength and suture holding capacity?
Submucosa
The early strength of the anastomosis depends on the suture holding capacity, which is predominantly in the …………?
Submucosa with the serosa
Why does the GIS mucosal and serosal injuries heal without scarring?
Bcz they heal with contraction not epithelization
What are the stages of wound healing?
1-hemostasis
2-inflammation
3-fibroplasia
4-maturation
How is a chronic wound distinguished?
-If it doesn’t get better in 3 months
-malignant transformation may be observed= MARJOLIN ULCER
During which period of wound healing does Angiogenesis(formation of new blood vessels) decreases and fibroplasia ends?
Maturation
Which one is stronger, the mechanical strength of an uninjured tissue or a scar?
Mechanical strength of an uninjured tissue
during which stage of wound healing are growth factor hormones released ?
during Hemostasis
*what are the proteins released during hemostasis from thrombin-activated platelets?
IGF-a
PDGF
TGF-a/b
vasoconstriction is seen in which stage of wound healing?
hemostasis
*what is the process of Hemostasis?
injury–>bleeding–>vasoconstriction–>platelets from the first plug–>coagulatıon factors–>Fibrin
[I Bleed Vaso in Platelet Plug then Coagulation occurs in Fibrin]
during which step is the thrombin-activated platelets start secreting its proteins, and what are they?
during hemostasis
proteins; IGF-1, TGF-a/b, PDGF
*what is the 5th stage in wound healing?
there’s no 5th stage`
*what are the signs of inflammation?
1-Rubor(redness.)
2-Dolor(pain)
3-Calor(fever)
4-Tumor(swelling)
………. release substances s.a histamine and serotonin that increase ……………..
Mast cells
increase vascular permeability
which stage of wound healing is characterized by the migration of leukocytes into wound?
2-inflammation
………………. are the first to arrive at the wound site
Polymorphonuclear neutrophils (PMNs) [are the most abundant innate immune cells in the body and act as the first defense against infections]
macrophage function in wound healing?
-secreted during inflammation
-2nd inflamm cell secreted
-fibroplastic proliferation
-phagocytosis of wound cell debris
***what is the function of T lymphocytes during inflammation step?
-peaks around 1 week after injury
-they bridge the transition from inflammation to proliferation
during which period is collagen synthesized?
fibroplasia/proliferation
the time b/w the injury and the onset of collagen in the healing wound is called the ……….
lag phase; in proliferation step
how long does it take for epithelialization to be completed in primary closure wounds?
48 hrs
which mech plays a role in the repair of full-thickness injuries s.a in tubular organs (bile duct, esophagus, colon)?
contraction
which mech plays a role in the repair of injuries that are not full-thickness s.a in skin or mucosa?
epithelialization
wound contraction is provided by …………?
myofibroblasts
are those local or systemic factors affecting wound healing?
mechanical injury
infection
edema
local
are those local or systemic factors affecting wound healing?
ischemia
topical agents
ionizing radiation
low O2 pressure
foreign body
local
are those local or systemic factors affecting wound healing?
age
nutrition
trauma
metabolic diseases
immunosuppression
systemic
are those local or systemic factors affecting wound healing?
connective tissue disease
smoking
drugs
systemic
are those local or systemic factors affecting wound healing?
mineral deficiency
vitamin deficiency
systemic
