Gastric Cancer Flashcards
Those That Increase the Risk of Gastric Cancer:
**Hypoacidity (85% of all gastric cancers)
** H. Pylori
• Atrophic gastritis (95% of all gastric cancers)
• Adenomatous polyp (especially > 2cm)
• Genetics
• Pernicious anemia
• A blood group
• Environmental factors
• Nitrites and Smoked
fish(3,4 benzopyrene)
• Aflatoxin
• Duodenal ulcer surgery
• Residual stomach after resection (especially Billroth II operation)
• Presence of gastric ulcer
• Presence of intestinal metaplasia
• Epstein Barr Virus (EBV)
Those that Reduce the Risk of Gastric Cancer:
Aspirin(salicylates)
Diet(fresh fruits, vegies)
Vitamin C
Which condition has highest risk for premalignancy in gastric ca?
Atrophic gastritis
Which condition has lowest risk for premalignancy in gastric ca?
Hyperplastic polyp
Early stage of gastric cancer is most common in ……?
Corpus/body of stomach
In which layer of the stomach is the early stage of gastric ca confined in?
Mucosa and submucosa of stomach
Tx of early stage gastric ca?
EMR (no need for surgery)
Or ESD
**Which is the most common subtype of type 2 early gastric ca classification?
Depressed-corpus
What is the classification of type 3 EARLY gastric ca ?
Excavated -corpus
Which type of gastric carcinoma is associated with H.pylori?
Intestinal type gastric carcinoma
Which type of gastric carcinoma is associated with poorly differentiated signet ring cells?
Diffuse type gastric carcinoma
Which type of metastasis is in intestinal vs. diffuse type gastric carcinoma?
In intestinal type —>hematogenous metastasis
(Lymphatic met is lower)
In diffuse type—> lymphatic metastasis (is more)
Which type of Lauren classification is more in female and which is more in male?
In female Diffuse
While
In males it is intestinal type gastric ca
Which cancer is treated with antibiotic?
Low-grade MALT Lymphoma (MALTOMA) ;caused by H pylori
Is a 10 cm submucosal gastric cancer early or late?
It is early bcz it is sill in submucosa
Tumor size is imp in GIST(intestinal);
Lesion 1cm> may behave as malignant
Gastric tumor size is
Not imp; only the layer in which the tumor invades is imp
Tx for gastric carcinoid?
Resection