**Pancreas Neoplasms

Question 1

which one is most common pancreatic neoplasm?

Answer 1

pancreatic ductal adenocarcinoma

Question 2

which one is the most rare pancreatic neoplasm?

Answer 2

acinar cell carcinoma of the pancreas

Question 3

what r the clinical features of pancreatic neoplasms?

Answer 3

Jaundice

pain(due to neuronal invasion)

weight loss

Question 4

**what is a specific clinical feature in tm located in pancreatic head(proximal)?

Answer 4

obstructive jaundice

Question 5

which location of pancreatic tm has the worst prognosis?

Answer 5

Pancreatic body and tail located tm

Question 6

what are the manifestations in Pancreatic body and tail located tm?

Answer 6

-Late symptoms
(worse prognosis)

– invasion of celiac artery and neighboring organs

-weight loss & fullness

Question 7

*the pancreatic tm is most likely to spread to which organs hematogenically ?

Answer 7

**liver
**lungs
adrenal glands
kidney
bone

Question 8

*what are the pancreatic tm markers?

Answer 8

**CA(cancer antigen) 19-9

CEA(carcinoembryonic antigen)

CA-50

Elastase-1

Question 9

**what is the most used and effective diagnostic method for pancreatic tm?

Answer 9

computed tomography (CT)
and
magnetic resonance (MR)
&
Endoscopic Retrograde Cholangiopancreatography (ERCP)

Question 10

*what is a procedure used for diagnosis and treatment of pancreatic neoplasm, why?

Answer 10

Endoscopic retrograde Cholangiopancreatography (ERCP)
[it’s invasive]

Bcz you can detect *DOUBLE DUCT SIGN, which is a sympt. of obstruction in bile duct and sphincter of Oddi (specific to pancreatic cancer)
+
a sample for examination can be taken by ERCP

Question 11

when do we take a biopsy for dx of pancreatic neoplasm?

Answer 11

when the pancreatic tm is unresectable

Question 12

which dx method is used for detection of staging metastasis vs chronic pancreatitis?

Answer 12

Positron-emission-tomography (PET): It is a new and very expensive examination
method that can distinguish between chronic pancreatitis and pancreatic cancer.

Question 13

what is the curative surgery for pancreatic neoplasm?

Answer 13

Pancreaticoduodenectomy (Whipple’s surgery); removal of head of pancreas, proximal duodenum, gall bladder, portion of bile duct, lymph nodes

Question 14

which type of dx method is not used in pancreatic neoplasm dx?

Answer 14

USG (ultrasonography)

Question 15

most pt in the late stage of pancreatic neoplasm will have….?

Answer 15

poor prognosis

Question 16

biopsy is done only in… then chemo and radiotherapy is given?

Answer 16

unresectable tumors

Question 17

Due to the rich
lymphatic and vascular structure of the pancreas, the tumor spreads ……………. by lymphogenous and hematogenous routes

Answer 17

prematurely

Question 18

what are the local invasions in pancreatic neoplasm?

Answer 18

– primarily retroperitoneal

– peripancreatic: duodenum, stomach, gallbladder, liver, peritoneum, adrenal

Question 19

how common are pancreatic neoplasms

Answer 19

13. most common cancer

Question 20

how common are pancreatic neoplasms DEATHS

Answer 20

8th place in cancer deaths