Parathyroid Surgical Disease Flashcards
Parathyroid hormone half life:
2-4 minutes
Inc PTH—>
Inc calcium
Dec phosphate
When calcitonin increases:
Decrease calcium
Decrease phosphate
When vitamin D increases
Calcium increase
Phosphate increase
Chronic renal failure is associated with which hyperparathyroidism?
Secondary hyperparathyroidism
Definition of primary hyperparathyroidism
“Malfunctioning” of the gland;
bcz of the disruption of the normal feedback control of serum calcium, the result is an increased PTH production in the parathyroid glands
What is MEN syndrome
MEN 1 and MEN2A both cause parathyroid hyperplasia;’
in MEN1 there’s over secretion of PTH which leads to bone break down then HYPERCALCEMIA then calcium kidney stones
Tertiary hyperparathyroidism
+characterized by excessive secretion of PTH after longstanding secondary hyperparathyroidism. in which hypercalcemia has ensued.
+Tertiary HPTH typically occurs in men and women with chronic kidney disease usually after kidney transplant.
seen in patients with renal failure who have undergone successful kidney transplantation. (Patients gained autonomy from the parathyroid gland.)
If PHPT is associated with MEN syndrome causes
Hyperplasia
Alkaline phosphatase increase shows
Hungry bone syndrome during PHPT
Diagnosis method for ECTOPIC localization primary hyperparathyroidism
SPECT-MIBI
What are the symptoms of PHPT
-Kidney stones( due to calcification)
-Polyuria, polydipsia, nocturia
-Abdominal pain (due to pancreatitis, cholylithiasis, Peptic ulcers)
-Hypertension
-Bone pain
-Depression
-Fatigue
-decreased apetite
To whom do you perform parathyroidectomy?
Under age of 50yrs
Patients with complications /symptoms
What are the surgical indications in asymptomatic hyperparathyroidism
Age<50 yrs old
Significant increase in calcium(8.5-10.5)
GFR<60
Life threatening hypercalcemic episode
What is parathyroid carcinoma symptoms?
Ca lvls above 14
PTH LVLS 5x than normal
Palpable parathyroid gland