Wnt signalling pathway Flashcards

1
Q

What is the name of the receptor that Wnt binds to?

A

Frizzled

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are two other proteins that Frizzled recruits once Wnt ligand binds?

A

LRP and DSH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the composition of the Wnt ligand?

A

Glycoprotein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the role of Evi protein?

A

Shunt lipid-modified Wnt signal to the surface of the cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the role of PORC?

A

Add lipid-modified Wnt to Evi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What function does the formation of a Frizzled/LRP complex serve?

A

Phosphorylation of GSK-3, part of the destruction complex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is responsible for endocytosis of the WNT signal complex

A

MVB

How well did you know this?
1
Not at all
2
3
4
5
Perfectly