Wnt signalling pathway Flashcards
1
Q
What is the name of the receptor that Wnt binds to?
A
Frizzled
2
Q
What are two other proteins that Frizzled recruits once Wnt ligand binds?
A
LRP and DSH
3
Q
What is the composition of the Wnt ligand?
A
Glycoprotein
4
Q
What is the role of Evi protein?
A
Shunt lipid-modified Wnt signal to the surface of the cell
5
Q
What is the role of PORC?
A
Add lipid-modified Wnt to Evi
6
Q
What function does the formation of a Frizzled/LRP complex serve?
A
Phosphorylation of GSK-3, part of the destruction complex
7
Q
What is responsible for endocytosis of the WNT signal complex
A
MVB