MicroRNAs and metabolism

Question 1

What does SREBP stand for?

Answer 1

Sterol Response Element Binding Proteins

Question 2

Define SREBP1

Answer 2

Regulates phospholipid and triacylglyceride biosynthesis

Question 3

Define SREBP2

Answer 3

Regulates cholesterol/sterol biosynthesis

Question 4

Define PPARs

Answer 4

A nuclear hormone receptors that activate peroxisomes responsible for decreasing the levels of lipds and cholesterols.
- Regulated by miR-27

Question 5

What is the process of making a sterol?

Answer 5

DMAPP + IPP = GPP

2 X GPP = Squalene

Squalene folds into a lanosterol

Question 6

What is miR-27

Answer 6

• Responsible for triglyceride accumulation in the liver cells
• inhibits adipogenic differentiation

Question 7

What is the link between HCV and miR-27?

Answer 7

• HCV uses miR-27 to induces triglyceride accumulation, leading to steatosis
• HCV does this because it relies upon the synthesis of fatty acids to replicate