VEGF pathway Flashcards
1
Q
What is the primary signalling VEGFR in blood vasculature
A
VEGFR2
2
Q
What is the role of effector proteins
A
To shunt VEGF-activated receptors toward clathrin coated pits
3
Q
What is the link between VEGF and tip cell formation
A
The endothelial cell that receives the most VEGF signal will become the tip cell
4
Q
Three ways that the VEGF pathway could be inhibited
A
- Bind to VEGF to prevent binding to receptor
- RTK inhibitor that prevents VEGFR cross-phosphorylation
- Blocks PTK kinase by covering ATP binding site
5
Q
What is the role of PTP1b?
A
It inhibits functioning of VEGFR2, thereby shutting down signal transduction
6
Q
What are the five VEGF proteins
A
VEGFA-D and placenta growth factor (PGF)
