TNF-alpha Flashcards
1
Q
What is TNF-alpha
A
- a cytotoxic factor that can induce apoptosis and inflammation pathways
- Induces caspase mediated cell death
- secreted from cell types like macrophages
- can bind to receptor either as a soluble or membrane-bound factor
2
Q
What are the two TNF-alpha receptors?
A
TNFR2 and TNFR1
3
Q
What is TRAAD?
A
- An adapter protein associated with TNFR1
- acts as a primary scaffold for signal transduction proteins associated with the TNF-alpha pathway
4
Q
Define NF-KB
A
- a transcription factor
- involved in inflammatory response and cell regulation
- helps activate MAPK pathways
5
Q
In what lung condition does TNF-alpha plays a role
A
Severe refractory asthma
6
Q
What is RIPK3?
A
RIPK is a signal factor that generates cell death when a virus like influenza is detected
7
Q
What is IKK?
A
IKK is a kinase responsible for activating NF-kB. It acts as an intermediate between signals like TNF-alpha and NF-kB.
- It possess the ability to react differently to diverse stimuli
8
Q
What happens when TNF activates IKK?
A
- fast response
- however, the TNF signal is quickly downregualted
- this makes TNF the INNATE response
9
Q
What happens when LPS signalling activates IKK?
A
- slower response
- however, signal is up-regulated, positive feedback
- a longterm signal that can spread to surrounding cells
