The SHH pathway

Question 1

Name the four different forms an SHH ligand can take

Answer 1

1. Monomer
2. Soluble multimer
3. Lipoprotein
4. Exovesicle

Question 2

The role of Patched and Smoothened in the canonical pathway

Answer 2

SHH binds to patched, preventing it from inhibiting smoothened. Smoothened will then activate Gli TFs

Question 3

What are the receptors sent out on filopodia towards SHH-containing filopodia?

Answer 3

PTC1