Week 6: Autoimmune liver disease

Question 1

What drugs are used to manage a variceal bleed in an acute and chronic (preventative) setting?

How do they reduce bleeding?

Answer 1

ACUTE: terlipressin

PREVENTION: propanolol

Both reduce portal pressure

Question 2

3 types of autoimmune liver disease

Answer 2

1. Primary biliary cholangitis
2. Autoimmune hepatitis
3. Primary sclerosing cholangitis

Question 3

Which ducts are affected in

• primary biliary cirrhosis
• primary sclerosing cholangitis

Answer 3

PBC: small ducts only (intrahepatic)

PSC: small and large ducts (intra and extrahepatic)

Question 4

High ALP + AMA suggest what autoimmune liver disease

Answer 4

PBC

Question 5

High ALP + ANCA suggest what autoimmune liver disease

Answer 5

PSC

Question 6

High ANA/ASMA suggest what autoimmune liver disease

Answer 6

Autoimmune hepatitis

Question 7

Histology: Granulomas and lymphocytes around bile ducts are features of what autoimmune liver disease

Answer 7

PBC

Question 8

Histology: lymphocyte infiltrates in hepatocytes are features of what autoimmune liver disease

Answer 8

Autoimmune hepatitis

Question 9

Histology: Onionskin fibrosis is a feature of what autoimmune liver disease

Answer 9

PSC

Question 10

String of beads appearance in MRCP is characteristic of what autoimmune liver disease

Answer 10

PSC

Question 11

Which autoimmune liver disease is associated with Sjogren’s

Answer 11

PBC

get dry eyes/ mouth

Question 12

Which autoimmune liver disease is associated with Ulcerative Colitis

Answer 12

PSC

get bloody diarrhoea