Week 3: Genetic tests and principles of inheritance

Question 1

What type of genomic test looks at the entire chromosome

Answer 1

Fluorescent in situ hybridisation (FISH)

Question 2

What type of genomic test looks at a small bit of chromosome

Answer 2

Array comparative genome hybridisation (aCGH)

Question 3

What type of genomic test looks at entire sets of chromosomes

Answer 3

Karyotyping

Question 4

In an autosomal dominant disorder, what is the chance of a child of an affected parent inheriting the disorder

Answer 4

50%

Question 5

In an autosomal recessive disorder, what is the chance of a child of 2 carrier parents inheriting the disorder

Answer 5

25%

Question 6

In an autosomal recessive disorder, what is the chance of a phenotypically normal child with an affected siblings being a carrier

Answer 6

2/3 chance

Question 7

In an X-linked disorder, what is the chance of a carrier female having an affected son

Answer 7

1/4 chance of son with dz

2/4 chance of carrier son

1/4 chance of normal son

Question 8

In an X-linked disorder, what is the chance of a carrier female having an affected daughter

Answer 8

1/4 chance of being carrier

Question 9

In an X-linked disorder, what is the chance of a son of an affected male being affected

Answer 9

Never

Question 10

In an X-linked disorder, what is the chance of a daughter of an affected male being affected

Answer 10

100%