Week 10: Myeloproliferative disorders Flashcards
List the 4 myeloproliferative disorders
- Polycythaemia vera
- Essential thrombocytosis
- Myelofibrosis
- Chronic myeloid leukaemia
Which myeloproliferative neoplasms are associated with the JAK2 mutation?
Which is the JAK2 mutation most specific for
- Polycythaemia vera (MOST SPECIFIC)
- Essential thrombocytosis
- Myelofibrosis
Which myeloproliferative neoplasms are associated with the Philadelphia chromosome
Chronic myeloid leukaemia
Changes in the levels of the following
- Hb
- Platelets
- WBC
with Essential thombocytosis
HIGH platelets only
Changes in the levels of the following
- Hb
- Platelets
- WBC
with Polycythemia vera
HIGH all 3 types
Changes in the levels of the following
- Hb
- Platelets
- WBC
with Primary Myelofibrosis
HIGH all 3 types intiially
After fibrotic stage, will get pancytopenia (LOW all 3 types)
Changes in the levels of the following
- Hb
- Platelets
- WBC
with CML
LOW Hb
HIGH platelets
HIGH WBC
What can be seen on the blood film in primary myelofibrosis
Teardrop poikilocytes
Pathophysiology of:
essential thrombocytosis
Diagnosis of exclusion
Isolated high platelets
Pathophysiology of:
primary myelofibrosis
Proliferation of structurally abnormal mature megakaryocytes -> leads to fibrosis in BM -> leads to BM failure
Pathophysiology of:
polycythaemia vera
Proliferation of mature myeloid cells and megakaryocytes
Pathophysiology of:
chronic myeloid leukaemia
proliferation of pluripotent haemotopoietic cells (may become myeloid/ lymphoid)
Pathophysiology of:
chronic lymphocytic leukaemia
Proliferation of mature-looking but non-functional B lymphocytes
Pathophysiology of:
acute myeloblastic leukaemia
Proliferation of precursor myeloid cells
Pathophysiology of:
acute lymphocytic leukaemia
Proliferation of precursor lymphoid cells
