Week 12: systemic disease rashes Flashcards
What skin markings/colouring are associated with Cushing’s
- stretch marks
- acne
What skin markings/colouring are associated with primary Addison’s (adrenal failure)
Hyperpigmentation
in buccal mucosa and palmar creases
What skin markings/colouring are associated with secondary adrenal failure
Ghostly white skin
Describe why primary and secondary Addison’s result in different coloured skin colouring
The same precursor hormone is split into ACTH and melanocyte stimulating hormone.
Secondary Addison’s = no ACTH or melanocyte stimulating hormone produced. So ghostly white skin
Primary Addison’s= ACTH and melanocyte stimulating hormone are still produced. Get hyperpigmentation instead
Triad of symptoms in Reiter’s syndrome
- Arthritis
- Uveitis
- Urethritis
Triad of symptoms in Behcet’s syndrome
- Oral ulcers
- Uveitis
- Genital ulcers
What is acanthosis nigricans?
What conditions is it associated with
Darkening of skin at skinfolds
- Diabetes
- Obesity
- Oesophageal gastric cancer
- Lung cancer
What is pyoderma gangrenosum?
What conditions is it associated with
Lesion in skin which looks pus filled (but is not due to infection)
- IBD
- RA + seronegative arthritis
- Leukaemia, myeloproliferative conditions
- Behcet’s disease
What is erythema migrans?
What conditions is it associated with
Target lesions
Associated with lyme disease (bite by tick carrying Borelia spirochetes)
What is erythema nodosum?
Where is it usually located
What conditions is it associated with
Red raised rashes on shin due to fat inflammation. Type of hypersensitivity response
- IBD
- Behcet’s
- Sarcoidosis, TB
- Strep infection
- Mycoplasma infection
- Non-Hodgkins lymphoma
- Pancreatic cancer
A purpuric rash in someone who also has the following symptoms is associated with what condition?
- abdo pain
- temperature
- renal symptoms
HSP
What kind of rash do you get in Coeliac’s disease
Dermatitis herpatiformis
