Week 12: General autoimmune dz

Question 1

Autoantibody for:

Antiphospholipid syndrome

Answer 1

Anti-cardiolipin

Question 2

Autoantibodies for:

Diffuse Systemic sclerosis

Answer 2

Anti-scl 70

RNA polymerase III

Question 3

Autoantibody for:

Polyangiitis granulomatosis

Answer 3

c-ANCA

Question 4

Autoantibody for:

Microscopic polyangiitis

Answer 4

p-ANCA

Question 5

Autoantibody for:

Rheumatoid arthritis

Answer 5

Rheumatoid factor

Question 6

Autoantibody for:

Sjogren’s syndrome

Answer 6

Anti-Ro

Question 7

Gene for for:

Ankylosing spondylitis/ seronegative spondyloarthropathies

Answer 7

HLA-B27

Question 8

Autoantibody for:

Polymyositis

Answer 8

Anti-Jo-1

Question 9

Autoantibody for:

SLE

Answer 9

dsDNA

Question 10

Autoantibody for:

Mixed connective tissue disease

Answer 10

Anti-RNP

Question 11

Autoantibodies for:

Localised Systemic sclerosis

Answer 11

Anti-centromere

Question 12

What order of colours do fingers tend to go during Raynaud’s

Answer 12

white -> blue -> red

Question 13

Does Raynaud’s present with diffuse or clearly demarcated redness

Answer 13

Clear demarcation between ischaemic and unaffected areas

Question 14

What medical conditions are associated with Raynaud’s

Answer 14

• SLE

- Sjogren’s

Question 15

What lifestyle factors cause Raynaud’s

Answer 15

• Smoking

- Cold exposure

Question 16

What medication can cause Raynaud’s

Answer 16

Beta blockers

Question 17

Women with autoimmune disease and what complications should be advised against pregnancy

Answer 17

1. Stage 4/5 CLD

2. Pulmonary hypertension

Question 18

How long should a woman have not had flare ups for before trying to get pregnant?

Answer 18

6 months

Question 19

What 2 drugs used to treat autoimmune disease are safe throughout pregnancy

Answer 19

1. Hydroxychloroquine

2. Azathioprine

Question 20

What investigation must never be forgotten in someone who has a flare up of SLE

Answer 20

Urine dipstick (looking for lupus nephritis)