Week 5 Eyes and Ears Flashcards
Opthalmic Anti-infectives Pharmacodynamics
Bacteriostatic or bactericidal
Ophthalmic Anti-infectives Phamacokinetics
•Generally penetrate only the
ocular fluid and tissues
•Minimal systemic absorption
Ophthalmic Anti-infectives Precautions and Contraindications
Hypersensitivity
Ophthalmic Anti-infectives ADR
Local infections
Superinfection with prolonged use
Ophthalmic Anti-infectives ADR - Bacitracin
may caused blurred vision
Ophthalmic Anti-infectives ADR - Sulfacetamide opthamic preperations
may cause a hypersensitivity reaction in
patients who have previously exhibited
sensitivity to sulfonamides
Ophthalmic Anti-infectives ADR - Aminoglycosides
may cause localizeed ocular toxicity
Ophthalmic Anti-infectives ADR - Fluoroquinolones
may cause a white christalline precipitate to form in the superficial portion of the cornea
Sulfacetamide ophtamic preparations are incompatiable with
silver preperations
Ophthalmic Anti-infectives: Patient
Education
Administration
Instruct on preventing contamination
Instruct on how to instill drops or ointment
• ADRs
Lifestyle management Handwashing No sharing of towels Avoiding use of eye makeup. Clearing purulent discharge with wet cotton ball or washcloth.
Glaucoma
Gradual loss of peripheral vision • Increased intraocular pressure • Leading cause of preventable blindness • Treated by ophthalmologist
Antiglaucoma Agents
Pharmacology • Beta blockers, adrenergic agonists • Miotics • Carbonic anhydrase inhibitors • Sympathomimetics • Prostaglandin agonist: latanoprost (xalatan) • Rho kinase inhibitor (metarsudil)
Mast cell stabilizers - use
conjunctivitis
mast cell stabilizes decrease
Limit hypersensitivity reactions
by inhibiting the degranulation of
sensitized mast cells.
mast cell stabilizer examples
•iodoxamide (Alomide), cromolyn
sodium (Crolom)
•Vernal conjunctivitis
Ocular anihistamines decrease what and are used to treat what
puritis
conjunctivitis
Ocular antihistamines work by blocking
H1 receptors
Ocular mast cell stabilizer and antihistamine side effects
Transient burning and stinging
Ocular antihistamine examples
•levocabastine (Livostin), antazoline (Vasocon-A, Antazoline-V), ketotifen (Zaditor), pheniramine (Naphcon-A), emedastine (Emadine) •Allergic conjunctivitis
Ophthalmic nonsteroidal anti-inflammatory drugs (NSAIDs) work by inhibiting
prostaglandin biosynthesis