Week 3 - A - Pathology 1 - Glomerulonephritis and Pyelonephritis (and renal function scans)) Flashcards
What is the renal parenchyma?
The renal parenchyma is the functioning part of the kidney that filters blood and makes urine
What is the difference between glomerulonephritis and pyelonephritis?
Glomerulonephritis is non-infective inflammation of the glomerular tufts leading to glomerular dysfunction
Pyelonephritis is infection in the kidneys
Glomerulonephritis primarily starts in the glomerular tufts before affecting other areas, where is affected secondarily?
In then goes on to have tubelointerstitial changes
There are a variety of different types of glomerulonephritis which we will be taught about Which type of glomerulonephritis is associated with changes to podocytes?
This would be minimal change glomerulonephritis (effacement of podocytes)
Why does the effacement (wiping out) of the podocyte foot process occur and what does this cause?
Thought to occur due to T cells releasing cytokines
This causes the negatively charged podocyte foot processes to be wiped out and therefore cant repel large proteins like albumin leading to the proteinuria and hypoalbuminaemia
What is the most common type of nephrotic syndrome seen in children?
This is minimal change nephrotic syndrome
What is the anti-glomerular basement antibody syndrome features? What is the syndrome known as?
Goodpasture’s syndrome
Glomerulonephritis and alveolar pulmonary haemorrhage causing haemoptysis
Pyeloneprhtiis is Bacterial infection of renal pelvis, calyces, tubules and interstitium.
What is the most common causative organism?
Escherichia coli
Pyeloneprhitis is usally caused by coliforms, name 2 of the coliforms and describe the distribution of infection?
Escherichia coli
Klebsiella pneumoniae
The infection of the kidneys usually has a patchy distribution
What other organ is also usually infected in pyelonephritis due to the ascending infection?
Cystitis - bladder
Why are girls more likely to get urinary tract infection? Why are pregnant women also more likely to get pyelonephritis?
They have a shorter urethra (4cm compared to 20cm)
Pregnant women have ureteric dilatation and therefore infection can more likely reach the kidneys
Any urinary tract obstruction can increase the chances of pyelonephritis Name some causes of urinary tract obstruction?
Renal caliculi
Prostatic hyperplasia
Strictures (in ureter)
Tumour, within or pressing on urinary tract
Congenital condition in which urine flows retrograde, or backward, from the bladder into the ureters/kidneys. (can be congenital, primary or it can be secondary due to ostruction)
This is known as vesicoureteric reflux - congenital is due to valves not closing properly leading to backflow of urine
The reflux can lead to infection and cause scarring of the bladder What can this scarring lead to?
Scarring can lead to secondary hypertension
What is one other condition that may predispose to pyelonephritis? Affects the sugar levels
Diabetes