Week 1 - C - Physiology 1 - Body fluid compartments Flashcards
What is the concentration of the osmotically active particles in a solution and what is its unit of measurement?
This is the osmolarity Unit of measurement is mosmol/l
What two things need to be known when calculating the osmolarity?
The number of osmotically active particles present and The molar concentration of the solution
Once knowing the number of osmotically particles present and the molar concentration of the solution, how is the osmolarity calculated? Define osmolarity to help calculate this
Osmolarity is the concentration of osmotically active particles present in a solution Osmolarity = Number of omsotically active particles multiplied by the concentration of the solution
The concentration is 150mM NaCl (150mM = 150mmol/l) Calculate the osmolarity of the solution
Concentration of the solution = 150mM Number of osmotically active particles = 2 Osmolarity = 150x2 = 300mosmol/l
The concentration of the solution is 100mM MgCl2 Calculate the osmolarity?
Osmolarity = concentration of the solution x number of osmotically active particles = 100 x 3 =300mosmol/L
What is the difference between the measurement of osmolarity and osmolality?
Osmolarity is the concentration of osmotically active particles in a solition (mosmol/l) Osmolality - concentration of osmotically active particles per kg (mosmol/kg) (For weak salt solutions (incl. body fluids) these 2 terms are interchangeable )
Ina normal person if there is an increased AHD secretion, what will this do to the osmolality of the blood?
This will decrease the osmolality
How does a water deprivation test show diabetes insipidus?
Patient is deprived of water In a normal person this would stimulate ADH production causing decreased blood osmolality and increased urine osmolality (increased water absorption) In a patient with diabetes insipidus , the urine osmolality will not increase as the body is not responding to/ or is not producing the ADH
The vasopressin test to differentiate between cranial and nephrogenic diabetes insipidus desmopressin (vasopressin analogue) is given How do the results differentiate between the two?
Cranial - urine osmolality will increase Nephrogenic - urine osmolality will remain low
A urine osmolality of what exlcudes diabetes insipdus?
Urine osmolality of >600mosmol/kg excludes diabetes inipidus
the effect a solution has on cell volume is known as what?
Its tonicity
What are the three types of tonicity?
Have an isotonic, hypotonic and hypertonic solution
What does a hypertonic solution cause to the cell size?
Hypertonic is high in solutes so this cause the osmotic gradient of water from inside the cell to outside resulting in shrinkage of the cell
What does a hypotonic solution cause?
Hypotonic soluton has more water than the cell which causes inflow of water which can cause cell lysis
What does an isotonic solution cause?
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