Week 1 - C - Physiology 4(A) - Proximal tubule reabsorption Flashcards
What is the major site of tubular reabsorption in the kidney?
The proximal convoluted tubule
What is the glomerular filtration rate value?
125ml/min - equates to roughly 180litres/day
What percentage of urea from the tubules is reabsorbed?
Only about 50%
Why is tubular reabsorption specific whereas as filtration is relatively non-specific?
This is due to the tubular reabsorption requiring specific transport processes
As kidneys filter at 125ml/min and the proximal tubules reabsorb at 80ml/min, what is the volume of blood entering the loop of Henle per minute?
45ml/min enter the loop of Henle
What happens to the osmolality of the blood as it travels through the proximal convoluted tubule?
It remains iso-osmotic (omsolarity does not change)
Describe the transcellular tubular reabsorption acorss the tubular lumen to the plasma?
Substance travels across tubular lumen and into the tubular epithelial cell Then travels across the cell and into the interstitial fluid before it reaches the plasma membrane of the peritubular capillary
What is the difference between transcellular and paracellular?
Paracellular travels in between the cells Transcellular is through the cell
There are different types of carrier-mediated membrane transport Primary active transport Secondary active transport Facilitated diffusion Describe each?
Primary active transport requires ATP as energy Secondary active transport is usually coupled to concentration gradient of an ion such as Sodium Facilitate diffusion is a carrier mediated down the concentration gradient - passive
Name one example of primary active transport where ATP is required to move ions?
The sodium potassium pump (3sodium out, 2potassium in, 1ATP)
What is the class of enzymes that phosphorylates ATP into ADP to provide energy for the sodium potassium pump?
ATPases
An energy-dependent Na+-K+ ATPase transport mechanism at the basolateral membrane is essential for Na+ reabsorption What happens here?
ATPase phosphorylates ATP to ADP which leads to 3Na leaving the tubular cell and travelling into the peritubular capillary and 2K entering the tubular cell
Where are sodium potassium pumps found?
Exclusively at the basolateral membranes of tubular cells
What is the difference between apical and basolateral?
The portion of the cell exposed to the lumen is called its apical surface. The rest of the cell (i.e., its sides and base) make up the basolateral surface. - basolateral is exposed to blood
At the apical membrane there is different transporters to bring sodium into the cell Why does there continue to be a concentration gradient where sodium is low inside the tubular cells and therefore is brought in from the lumen?
This is due to the Na+/K+/ATPase pump which continually actively transport sodium out of the cell and into the interstitial fluid