Week 2 - Autoimmunity

Question 1

what are seropositive conditions?

Answer 1

rheumatological conditions which involve auto-antibodies

Question 2

what can cause the loss of immune regulation which results in formation of auto antibodies?

Answer 2

multifactorial

genetic predisposition combined with environmental insult such as infection or prolonged chemical exposure

Question 3

give an example of an organ specific autoantibody?

Answer 3

those causing auto immune thyroid disease

Question 4

which type of auto antibody causes more varied symptoms, organ specific or systemic?

Answer 4

systemic

but still generally fit within a pattern of disease

Question 5

anti CCP antibody?

Answer 5

Rheumatoid arthritis

Question 6

SLE antibodies?

Answer 6

anti dsDNA (mainly)
ANA
Anti Sm
Anti Ro
Anti RNP

Question 7

Sjogrens antibodies?

Answer 7

Anti Ro
Anti La
ANA

Question 8

Systemic Sclerosis antibodies?

Answer 8

Anticentromere(limited)
antitopoitomerase
ANA
Anti Scl 70 (diffuse)antibody

Question 9

mixed connective tissue disease antibodies?

Answer 9

ANA

Anti RNP

Question 10

anti phospholipid syndrome antibodies?

Answer 10

lupus anticoagulant
anti cardiolipin
beta 2 glycoprotein

Question 11

myositis antibody?

Answer 11

anti Jo - 1

Question 12

small vessel vasculitis antibody?

Answer 12

anti neutrophil cytoplasmic antibody (ANCA)