week 10 Flashcards
Digestive system
Steps in digestion
- Ingestion 2.Mechanicalprocessing 3.Digestion
- Secretion
- Absorption
- Excretion
Mechanical digestion
- Segmentation
* Constantstirringandmixing •NBforwardmovementviaperistalsis(weakerandslowerhere
Chemical digestion
- ENZYMES!!!
- Catabolicprocess–itisnecessarytobreakthe fooddowninto‘bits’smallenoughtobe absorbedacrosstheintestinalepithelium
Enzyme
“Aproteinthatcatalysesaspecificbiochemicalreaction”
Large interstine
- Reabsorptionofwater
- Reabsorptionofbilesalts •Absorptionofvitaminsproducedbybacteria •Absorptionoforganicwastes(generatedbybacteria)
- Peristalticwaves
Thedefecationreflex
Two positivefeedback loops
1.Short reflex (local)
•Triggers peristaltic contractions in rectum
2.Long reflex (PSNS –reflex through spinal cord) •Coordinated by sacral parasympathetic system •Stimulates mass movement
Digestive tract
- Digestivetractakagastrointestinal(GI) tractoralimentarycanal
- Musculartube
- Extendsfromoralcavitytoanus •Passesthroughpharynx,esophagus,stomach,andsmallandlargeintestines
Role of the GIT
- Largeorganic masses
- smallerparticles
- fuel
- Digestsand absorbsfood
- ACATABOLICprocess
Functions of the GIT
- Ingestion–foodintomouth
- Digestion–breakingfoodintoeversmallerbits •Mechanical(chewing,mixing,churning,segmentation) •Chemical(enzymes…catabolism)
- Secretion–intotheGIT
- Absorption–endproductintobloodorlymph
- Defecation–elimination/excretion
- Motility/Propulsion‐movingthingsalong
- Defence–againstGITcontents,mechanicalstress,potential pathogens
Movement of digestive materials
- By muscular layers of digestive tract
- Along digestive tract –Rhythmic cycles of activity –Controlled by pacesetter cells
- Cells undergo spontaneous depolarization –Triggering wave of contraction through entire muscular sheet
Peristalsis
– Consists of waves of muscular contractions
– Moves a bolus along the length of the digestive tract
Segmentation
– Cycles of contraction
•Churn and fragment the bolus
•Mix contents with intestinal secretions
–Does not follow a set pattern
•Does not push materials in any one direction
Functions of oral cavity
•Sensoryanalysis
–Ofmaterialbeforeswallowing
•Mechanicalprocessing
–Throughactionsofteeth,tongue,andpalatalsurfaces •Lubrication
–Mixingwithmucusandsalivaryglandsecretions •Limiteddigestion
–Ofcarbohydratesandlipids
Saliva
Composition
- 99.4%water
- 0.6%includeselectrolytes(Na+,Cl‐,andHCO3‐),buffers,glycoproteins (mucins),antibodies,enzymes,wasteproducts
Functions
–Cleaning‐continuouslyflushesoralsurfaces
–Protection
–buffers,antibodies,lysozyme
–Lubricatingthemouth
–Moisteningandlubricatingmaterialsinthemouth
–Dissolvingchemicalsthatstimulatetastebudsandprovidesensory information
–Initiatingdigestion‐salivaryamylase,linguallipase(?)
Oesophagus
•Fromlaryngopharynxtostomach •Piercesdiaphragm“oesophagealhiatus” •Joinsstomachatthecardiacorifice •Glandsinsubmucosasecretemucus
•Muscularis
–skeletal‐superiorly
–smooth‐inferiorly
Three phases of swallowing
Buccal
Pharyngealphase
Oesophagealphase
Major functions of the stomach
- Storageofingestedfood •Mechanicalbreakdownofingestedfood •Disruptionofchemicalbondsinfoodmaterialbyacidandenzyes
- Productionofintrinsicfactor,aglycoproteinrequiredforabsorptionofvitaminB12 insmall intestine
- Althoughdigestionoccursinthestomach,nutrientsarenotabsorbed
Stomach layers
Mucosa
Submucosa
Muscularis externa
Serosa
Structure Alimentary canal
Mouth
Oesophagus
Stomach
Small intestine
Structure AccessoryOrgans
Teeth Tongue Salivary glands Gall bladder Liver Pancreas
Small intestine
•Playskeyroleindigestionandabsorptionofnutrients •90percentofnutrientabsorptionoccursinthesmallintestine •3parts:duodenum,jejunum,ileum
Intestine
Duodenum
•Receives chyme from stomach and digestive secretions from pancreas and liver
•Acid neutralisation
Jejunum
•Location of most chemical digestion and nutrient absorption
Ileum
•Little nutrient absorption
•Ends at the ileocecal valve
•Lymphoid tissue (Peyer’s patches)
Liver
•Largestvisceralorgan(1.5kg) •4lobes •200+functions! •Relatedtodigestion –Processblood‐bornenutrientsabsorbedfromSI –Producebile= 900mL/day •Importantforfatdigestion –Storesfat‐solublevitamins –Detoxifies •Toxins •Includingmanydrugs