week 1

Question 1

what is arthritis

Answer 1

joint pain

Question 2

what system is the locomotor system

Answer 2

musculoskeletal

Question 3

other roles of musculosketetal system

Answer 3

hematopoeitic, mineral storage

Question 4

what is a developmental anomaly of bone called

Answer 4

dysostosis

Question 5

what is a homeobox gene

Answer 5

structural development during embryologic development

Question 6

3 types of dysostosis

Answer 6

aplasia, supernumerary digits, abnormal fusion of bones

Question 7

what is aplasia

Answer 7

absent/incomplete develop

abnormal fxn

Question 8

what is dysplasia

Answer 8

mutations interfere w/ growth or homeostasis (dwarfism)

Question 9

is dysplasia pre-cancerous

Answer 9

no

Question 10

example of sysostosis

Answer 10

klippel-feil - lower cervicals fuse

Question 11

what symptoms typically goes w/ kippel feil

Answer 11

sprengels deformity

Question 12

what is aka brittle bone disease

Answer 12

osteogenesis imperfecta

Question 13

osteogenesis imperfecta has mutations to what

Answer 13

collagen 1

Question 14

how is osteogenesis imperfecta classified

Answer 14

type 1: normal

type 2: lethal in utero

Question 15

what type of collagen do each of the types of osteogenesis imperfecta have

Answer 15

type1 = 1

type 2= 1

Question 16

what is the most common form of dwarfism

Answer 16

achondroplasia

Question 17

in acondroplasia a decrease in cartilage synthesis causes a decrease in…

Answer 17

growth plate expansion

Question 18

is acondroplasia usually spontaneous or autosomal dominant

Answer 18

spont: 75%
auto: 25%

Question 19

what is the big deal about achondroplasia and spine

Answer 19

they are exaggerated, bullet vertebrae, scoliosis and spinal stenosis

Question 20

what is the type of achondroplasia that is lethal

Answer 20

thanatrophic dwarfism, small thorax

Question 21

what disease has blue sclera and brittle bones

Answer 21

osteogenesis imperfecta

Question 22

what disease is associated with mutated fgfr3

Answer 22

achondroplasia

Question 23

what is disease has rare genetic decrease in osteoclast bone absorption

Answer 23

osteopeTrosis

Question 24

what does osteopetrosis cause

Answer 24

skeletal sclerosis (stone like)

Question 25

what is a prob that can happen to bones other than sclerosis in osteopetrosis

Answer 25

medullary cavity fills: issue w/ hematopeoisis

Question 26

how to treat osteopetrosis

Answer 26

stem cell replacement

Question 27

list order of bone disease…

Answer 27

normal -> osteopenia-> osteoperosis

Question 28

what disease has frontal bossing, extremity bowing, and short proximal extremities

Answer 28

achondroplasia

Question 29

what happens in osteoporosis

Answer 29

decrease mass = inc in porosity

Question 30

what does the t score have to be for osteoporosis

Answer 30

2.5 sd

Question 31

when would you get localized osteoporisis

Answer 31

disuse

Question 32

what is the mc osteoporosis generalized to the entire skeleton

Answer 32

senile and post menopausal

Question 33

why are corticosteroids so bad for bones

Answer 33

rob bone of ca

Question 34

what does osteoporosis typically attack

Answer 34

trabecular bone: calcaneus, vert body, and femoral neck

Question 35

what causes senile osteoporosis

Answer 35

decrease in GF causes dec in osteoblast activity

Question 36

how much bone is lost per yr avg

Answer 36

.5% beg in mid-20s

Question 37

why does postmenopausal accelerate bone loss

Answer 37

dec in estrogens