miscellaneous bone tumors

Question 1

what is difference between fibrous cortical defect and nonossifying fibroma

Answer 1

size <5= FCD

NOF= 5-6 cm

Question 2

what is the tx of FCD and NOF

Answer 2

usually none: differentiate into cortical bone by adolescence, biopsy is not usually required

Question 3

What are the categories of fibrous dysplasia from spontaneous

Answer 3

1. monostatic
2. polyostotic: multiple bone involvement
3. polyostotic and cafe au lait spots and endocrinopathy

Question 4

what is the disease of polystatic and cafe au lait spots

Answer 4

McCune Albright syndrome

Question 5

Which is the most common type of fibrous dysplasia

Answer 5

monostatic: 70%

Question 6

describe polystotic fibrous dysplasia

Answer 6

severe deformation usually craniofacial (50%)

Question 7

when is McCune- Albright Syndrome MC

Answer 7

early puberty

Question 8

which has “onion skinning” of periosteum

Answer 8

ewing sarcoma

Question 9

which tumors are not true neoplasms

Answer 9

fibrous cortical defect and nonossification fibroma

Question 10

which has neoplastic mononuclear cells

Answer 10

giant cell tumor of bone (GCT)

Question 11

what happens in GCT

Answer 11

erode cortex, large, lytic

Question 12

is there pain with GCT

Answer 12

yes, arthritis like, eccentric

Question 13

what percent of GCT metastasize and where

Answer 13

2%, and lungs

Question 14

where is 2* metastasis to bone MC

Answer 14

axial skeleton, proximal femur/humerus

red marrow

Question 15

osteoarthritis is degeneration of

Answer 15

articular cartilage

Question 16

which is 1* and 2*, and to who?
insidious, no trauma
injury

Answer 16

1* adults

2* kids

Question 17

MC areas of osteoarthritis

Answer 17

spine, dip joints, 1st mcp, 1st tmt joint

Question 18

females usually get osteoarthritis….

males

Answer 18

knees and hands

hips

Question 19

softening and degragation associated with osteoarthritis

Answer 19

chondromalacia

Question 20

sclerosis of bone associated with osteoarthritis

Answer 20

eburnation

Question 21

which tumor has a “soap bubble appearance”

Answer 21

GCT: giant ell tumor

Question 22

when does inflammation develop in relation to osteoarthritis

Answer 22

2*

Question 23

what are subchondral cysts

Answer 23

when synovial fluid flows in due to subchondral fractures

Question 24

which antibodies are associated with RA

Answer 24

anti-ccp

Question 25

how many cases of RA are associated with anti ccp

Answer 25

70%

Question 26

IgM antibodies w/ RA

Answer 26

80%

Question 27

what kind of fever is associated with RA

Answer 27

low grade

Question 28

who is more likely to have RA

Answer 28

3-5x

Question 29

which arthritis has ankylosis

Answer 29

RA

Question 30

juvenile RA attacks what

Answer 30

large joints

Question 31

what qualifies as juvenile RA

Answer 31

6wks

Question 32

which disease has the acronym PEAR

Answer 32

seronegative spondyloarthropathies

Question 33

what does PEAR stand for

Answer 33

psoriatic arthritis
enteropathic arthritis
ankylosing spondylitis (AS)
reactive arthritis

Question 34

ankylosing spondylitis attacks what joint mainly

Answer 34

SI

Question 35

what happens to the spine in ankylosing spondylitis

Answer 35

syndesmophytes: “bamboo spine”

Question 36

when is the onset of AS

Answer 36

<40 yrs old

Question 37

which gene is involved w/ AS

Answer 37

HLA-B27

Question 38

what disease has abnormal purine metabolism

Answer 38

gout

Question 39

what is there a build up of in gout

Answer 39

urate crystals

Question 40

of cases that 1* gout is idiopathic

Answer 40

90%

Question 41

3 ways to “feel gout”

Answer 41

1. asymptomatic hyperuricemia
2. acute gouty arthritis: cycles
3. chronic tophoceous arthritis: fails to resolve between cycles

Question 42

what is the worry of chronic tophoceous arthritis

Answer 42

renal failure (gouty nephropathy)

Question 43

what disease goes w/ can’t pee, can’t see, can’t dance w/ me

Answer 43

reactive arthritis