Week 1 Flashcards

1
Q

What is the function of the respiratory system

A

Designed to allow easy efficient gas exchange (uptake of oxygen and release of co2).
Other functions- metabolic functions such as production of surfactant IGA acting as a blood reservoir, phonation and regulation of acid and base balance by co2 removal

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2
Q

What is the function of the cardiovascular system

A

Designed to efficiently deliver oxygen to the tissues and remove waste products of metabolism. Blood flow and delivery of oxygen matches the metabolic needs at any particular time

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3
Q

Organ systems are arranged in parallel or series

A

Parallel

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4
Q

Are pulmonary and systemic cardiovascular systems arranged in series or parallel

A

Series

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5
Q

What is diffusion a result of

A

The movement of molecules due to their thermal motion

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6
Q

What is rate of diffusion directly proportional to

A

Concentration gradient

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7
Q

What is facilitated diffusion

A

Molecules move down their concentration gradient through carrier protein/ion channel
Electrochemical equilibrium consists of chemical driving force and electrical driving force

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8
Q

As the concentration gradient increases what should happen to the net flux

A

The net flux should increase as the concentration gradient increases
At a high permeability the graph should be steeper
Graph of concentration gradient and net flux
Y axis net flux
X axis concentration gradient

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9
Q

What is facilitated diffusion

A

Molecules move down their concentration gradient through carrier protein ion channel
Electrochemical equilibrium consists of chemical driving force and electrical driving force

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10
Q

The magnitude of driving force affects the rate of diffusion what are other factors

A

Membrane surface
Membrane permeability affected by temperature thickness size shape of diffusion substance and lipid solubility of the diffusing substance

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11
Q

What is a channel protein

A

Forms a pathway through the membrane, ion channels are highly selective and quick but they cannot be used to perform active transport. Most channels are gated (voltage/ligand)

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12
Q

What is a carrier protein

A

Picks up the substance and deposits them on the other side the substance binds to the protein causing a conformational change resulting in deposition of the substance on the other side

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13
Q

what three types of transporters can channel proteins be

A

Uniporters (example glucose uniporter)
A symporter na+/ glucose symporter
Antiporter band 3 protein for hco3/cl

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14
Q

Give an example of a uniporter

A

Glucose

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15
Q

Give an example of a symporter

A

Na+ glucose symporter

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16
Q

Give an example of an antiporter

A

Hco32-/cl band 3 protein.

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17
Q

What can block na+/k+ ATP are pump

A

Ouabain

18
Q

Why is the na+/k+ pump important

A

Maintains osmotic balance and cell volume

19
Q

What happens in the na/ka pump is blocked for example by ouabain

A

There tends to be an influx of sodium and out flux of potassium. Due to the sodium ions entering, water enters the cell and causes it to burst

20
Q

What is active transport

A

Can be primary which means it uses ATP
Or secondary uses the energy from the electrochemical gradient or concentration gradient created by primary active transport

21
Q

What is primary active transport

A

Uses ATP

22
Q

What is secondary active transport

A

Uses energy from electrochemical gradient created by primary active transport

23
Q

What is the intracellular concentration of sodium

A

20mM

24
Q

What is the extra cellular concentration of sodium

A

145 mM

25
Q

What woukd be the movement due to concentration gradient alone of sodium ions

A

Into the cell

26
Q

What is the intradellular concentration of potassium

A

150mM

27
Q

What is the extra cellular concentration of potassium

A

4mM

28
Q

What is the intracellular concentration of chloride ions

A

6mM

29
Q

What is the extra cellular concentration of chloride ions

A

125mM

30
Q

What is the movement due to concentration gradient alone of chloride ions

A

Into the cell

31
Q

What is the movement due to concentration gradient alone of potassium ions

A

Out of the cell

32
Q

What is the movement due to voltage difference between inside and outsides of potassium ions

A

Inside the cell

33
Q

What is the movement due to voltage difference between inside and oitside sodium ions

A

Into the cell

34
Q

What is the movement due to voltage difference between inside and outside of chloride ions

A

Out of the cell

35
Q

In a sodium potassium pump, what causes an efflux of potassium out of the cell

A

Slight depolarisation by entry of sodium causes efflux of potassium out of the cell. A new membrane potential is reached where outward potassium movement balances inward sodium movement

36
Q

What ions contribute to resting potential the most

A

Potassium ions contribute to most of resting potential, sodium ions have a tendency to move into the cell but have a low permeability at resting state

37
Q

Why do sodium and potassium movemrnt from the na+ / k+ not change the membrane potential

A

The sodium and potassium movement do not change membrane potential, there is a change in concentration gradients of the two ions across the membrane. The passive flux of these ions is balanced by active pumping of the ions by the na+ k+ atp ase pump

38
Q

Definition of equilibrium potential

A

The potential needed to prevent ions from moving down their concentration gradient across the membrane.

39
Q

What is the nernst equation used for

A

To determine the equilibrium potential for each particular ion
E=RT/Zf x ln[ion]o/[ion]i

40
Q
A