acid base balance Flashcards

1
Q

acids release what type of ions

A

h+ ions

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2
Q

bases accept what type of ions

A

h+ ions

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3
Q

what does acidity refer to

A

the amount of unbound h+

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4
Q

what form are volatile acids in inside the lung

A

gaseous form and can be removed by lungs

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5
Q

what organs non volatile (fixed) acids removed by

A

kidneys

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6
Q

how do strong acids dissociate

A

fully

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7
Q

how do weak acids dissociate

A

partially

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8
Q

what does changing the ph interfere with

A

enzymatic activity

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9
Q

what is the optimum ph margin

A

7.35-7.45

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10
Q

below what ph would be acidosis

A

7.35

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11
Q

above what ph would be alkalosis

A

7.45

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12
Q

how do buffer systems resist changes in ph

A

reversibly bind h+

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13
Q

what are the two main intracellular buffers

A

phosphate and protein

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14
Q

what is the main blood/extracellular buffer

A

hco3-

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15
Q

what does pka of a buffer mean

A

the ph that it works best at

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16
Q

why is the henderson-hasselbach equation important

A

describes the relationship between ph and the buffer system and explains why its a good buffer

17
Q

what are the four types of acidosis and alkalosis

A

respiratory acidosis
metabolic acidosis
respiratory alkalosis
metabolic acidosis

18
Q

explain respiratory acidosis

A

hypoventilation
pco2 rises
hco3-/po2 ratio falls
ph falls below 7.35
kidney reabsorbs hco3-
hco3-/pco2 ratio normalises with a base excess
compensated respiratory acidosis

19
Q

explain respiratory alkalosis

A

hyperventilation
pco2 falls
hco3-/po2 ratio rises
ph rises above 7.45
kidney excretes hco3-
hco3-/po2 ratio normalises when there is a base deficit
compensated respiratory alkalosis

20
Q

explain metabolic acidosis

A

tissue hypoxia/ketoacids
hco3- falls
hco3- falls
hco3-/pco2 ratio falls
ph falls
increase in ventilation lowers pco2
hco3-/po2 ratio normalises with a base deficiet
compensated metabolic acidosis

21
Q

explain metabolic alkalosis

A

excessive ingestion of alkalis/loss of gastric acid
mild hypoventilation increases pco2
hco3- increases
hco3-/pco2 ratio increases
ph above 7.45
hco3-/po2 ratio semi normalises with base excess
partially compensated metabolic alkalosis

22
Q

what is the simplified henderson hasselbach equation

A

ph=constant+kidney/lungs

23
Q

how many ways can acid base ratio be disturbed

A

4
increased pco2 and decreased hco3-
increased hco3- and decreased pco2
decreased hco3-
decreased pco2 and increased hco3-