Week 1 Flashcards

1
Q

Before the 1990’s only ____ young and middle aged participated in trails.

A

Men

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2
Q

Nonproprietary name

A

Generic

Ex: Acetaminphen

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3
Q

Proprietary name

A

Brand Name

Ex: Tylenol

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4
Q

What the body does to the drug

A

Pharmokinetics

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5
Q

What are the 4 steps of the Pharmacokinetic Process?

A

Absorption
Distribution
Metabolism
Excretion

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6
Q

What are the factors that affect drug absorption?

A
Rate of dissolution
Surface area (greater the better)
Blood Flow
Lipid Solubility
pH partitioning
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7
Q

Absorption is how meds are ____

A

Administrated

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8
Q

Slowest rate of absorption

A

Oral

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9
Q

Quickest way of absorption

A

IV

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10
Q

Movement of the drug to interstitial space

A

Distribution

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11
Q

Chemical alteration of drug structure

A

Metabolism

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12
Q

What are some special considerations when dealing with drug metabolism?

A
Age
Induction
First-pass effect
Nutritional status
Competition between drugs
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13
Q

What is the first pas effect?

A

When the drug first passes through the liver

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14
Q

What are the steps in renal drug excretion?

A

Glomerular Filteration
Passive reabsorption
Active transport

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15
Q

What are some ways of non-renal excretion?

A

Breast milk, bile, lungs, sweat, saliva

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16
Q

Biochemical and physiological effects of drug on body

A

Pharmacodynamics

17
Q

Efficacy is about ____.

A

Effectiveness

18
Q

Potency is about ____

A

Dose

19
Q

Drug-Related Variables?

A

Dosage
Route of administration
Drug-diet interactions
Drug-Drug interactions

20
Q

Patient-Related Variables?

A
Age
Body weight 
Pharmacogenetic
Gender
Pre-existing conditions
Psychological factors
21
Q

What is one of the biggest drug-food interactions?

A

Grapefruit juice effect

22
Q

What are the 6 rights?

A
Patient
Route
Drug
Time
Dose
Documentation