COX Inhibitors Flashcards
What are adjuvants used for?
To compliment the effects of opioids
What are some examples of adjuvants?
Antidepressants
Anti-seizure drugs
Anesthetics
What are the four cyclooxygenase inhibitors?
Aspirin
Ibuprofen
Celecoxib
Acetominophen
What is the drug that lack anti-inflammatory actions?
Acetaminophen
What are the four key functions of aspirin?
Analgesic, anti-inflammatory, antipyretic, anti-platelet
What is the MOA of aspirin?
Irreversibly inhibits COX 1 & 2
What is a manifestation of an aspirin overdose?
Tinnitus
What is the high dose and low dose of aspirin?
High Dose - 325 mg
Low Dose - 81 mg
Why do you not give children aspirin?
They can develop Reyes syndrome
What is one serious adverse effect of Aspirin?
Salicylism (toxicity)
Why do you take aspirin with food?
Because it causes GI upset and affect renal function
What generation is ibuprofen?
1st Generation
What generation is Celebrex?
2nd Generation
What are the 3 key function of ibuprofen?
Pain
Fever
Inflammation relief
What medication is not used to prevent MI or CVA?
Ibuprofen
Why is Celebrex a last choice drug?
Because it can increase risk of MI or CVA
What is the MOA for Celebrex?
Suppresses inflammation, pain, and fever
What are the two key function of Acetaminophen?
Pain and fever
What is the MOA for acetaminophen?
Inhibits prostaglandin synthesis
What are the serious adverse effects of Acetaminophen?
Overdose can lead to hepatotoxicity
Steven Johnson Syndrome
What is the reversal agent of Acetaminophen?
Acetylcysteine
What are some nursing implications of CO inhibitors?
Assess for anemia/bleeding
Encourage enteric coated
Assess for CVA/MI for Celebrex
What are some nursing implications for Acetaminophen?
Liver Function Test
History of Liver issues and Alcohol use
What are the signs of liver toxicity?
Nausea Vomiting Diarrhea Sweating Abdominal pain
What lab would you look at to assess a GI Bleed?
BUN
What lab would you look at to assess an issue with the kidneys?
Creatinine
