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Pharm Test 1 > COX Inhibitors > Flashcards

COX Inhibitors Flashcards

1
Q

What are adjuvants used for?

A

To compliment the effects of opioids

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2
Q

What are some examples of adjuvants?

A

Antidepressants
Anti-seizure drugs
Anesthetics

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3
Q

What are the four cyclooxygenase inhibitors?

A

Aspirin
Ibuprofen
Celecoxib
Acetominophen

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4
Q

What is the drug that lack anti-inflammatory actions?

A

Acetaminophen

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5
Q

What are the four key functions of aspirin?

A

Analgesic, anti-inflammatory, antipyretic, anti-platelet

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6
Q

What is the MOA of aspirin?

A

Irreversibly inhibits COX 1 & 2

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7
Q

What is a manifestation of an aspirin overdose?

A

Tinnitus

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8
Q

What is the high dose and low dose of aspirin?

A

High Dose - 325 mg

Low Dose - 81 mg

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9
Q

Why do you not give children aspirin?

A

They can develop Reyes syndrome

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10
Q

What is one serious adverse effect of Aspirin?

A

Salicylism (toxicity)

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11
Q

Why do you take aspirin with food?

A

Because it causes GI upset and affect renal function

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12
Q

What generation is ibuprofen?

A

1st Generation

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13
Q

What generation is Celebrex?

A

2nd Generation

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14
Q

What are the 3 key function of ibuprofen?

A

Pain
Fever
Inflammation relief

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15
Q

What medication is not used to prevent MI or CVA?

A

Ibuprofen

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16
Q

Why is Celebrex a last choice drug?

A

Because it can increase risk of MI or CVA

17
Q

What is the MOA for Celebrex?

A

Suppresses inflammation, pain, and fever

18
Q

What are the two key function of Acetaminophen?

A

Pain and fever

19
Q

What is the MOA for acetaminophen?

A

Inhibits prostaglandin synthesis

20
Q

What are the serious adverse effects of Acetaminophen?

A

Overdose can lead to hepatotoxicity

Steven Johnson Syndrome

21
Q

What is the reversal agent of Acetaminophen?

A

Acetylcysteine

22
Q

What are some nursing implications of CO inhibitors?

A

Assess for anemia/bleeding
Encourage enteric coated
Assess for CVA/MI for Celebrex

23
Q

What are some nursing implications for Acetaminophen?

A

Liver Function Test

History of Liver issues and Alcohol use

24
Q

What are the signs of liver toxicity?

A 
Nausea
Vomiting
Diarrhea
Sweating
Abdominal pain
25
Q

What lab would you look at to assess a GI Bleed?

A

BUN

26
Q

What lab would you look at to assess an issue with the kidneys?

A

Creatinine

Pharm Test 1 (15 decks)

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