Muscle Spasm/Spasticity Drugs

Question 1

What medication is used as a muscle relaxer for spasticity?

Answer 1

Baclofen

Question 2

What medication is used as a muscle relaxer for localized muscle spasm?

Answer 2

Cyclobenzaprine (Fexmid, formally flexural)

Question 3

What is a direct acting muscle relaxer?

Answer 3

Dantrolene

Question 4

What is the primary use of baclofen?

Answer 4

Spasticity from spinal cord injuries

Question 5

What is the MOA for Baclofen?

Answer 5

Suppress hyperactivity

Structural analog of GABA

Question 6

What are the adverse effects of Baclofen?

Answer 6

CNS Depressant
Headache
N/V
Constipation 
Withdrawel

Question 7

What are some indications you should assess for before administering Baclofen?

Answer 7

Opioids
Benzo’s
Anticholinergics
Benign prostatic hypertrophy

Question 8

What is the MOA of Dantrolene?

Answer 8

Acts directly on skeletal muscle by suppressing release of calcium

Question 9

What are the common uses for Dantrolene?

Answer 9

Spasticity
Malignant Hyperthermia
Rigidity

Question 10

What are the adverse effects of Dantrolene?

Answer 10

Hepatic toxicity

Diarrhea