Osteoporosis Flashcards
What is the most common disorder of calcium metabolism?
Osteoporosis
What are the three primary preventions of osteoporosis?
Calcium
Vitamin D
Lifestyle
What is the use of Calcitonin-Salmon?
Used in the treatment, not prevention, of osteoporosis
What is the MOA of Calcitonin-Salmon?
Mimics calcitonin by inhibiting osteoclast activity and promoting renal excretion or calcium
What class of drug is Alendronate?
Bisphosphonate
You can use Alendronates regardless of what?
Gender
What is the MOA of Alendronate?
Suppresses bone resorption by decreasing osteoclast activity
What is the appropriate dosing for Alendronate?
AM on an empty stomach
Sit up right for 30 mins
What are the adverse effects of Alendronate?
Esophagitis
What do you assess for before administering Alendronate?
History of Pregnancy
Any disorder that can impede swallowing
What drug class does Evista (Raloxifene) belong to?
Selective Estrogen Receptor Modulator (SERM)
What is Raloxifene used for?
Osteoporosis; preserves Bone Mass Density; reduces spinal fractures by 55%
What is the MOA of Raloxifene?
Structurally similar to estrogen
Can behave as an agonist or antagonist
What are some adverse effects of Raloxifene?
May increase her flashes
Leg cramps
Thromboembolic events
What do you want to assess for before administering Raloxifene?
History of Pregnancy
history of VTE
What interventions and evaluations should you expect with Raloxifene?
If client will experience prolonged immobility, medication should be stopped 72 hours prior
S/S of difficulty breathing, weakness on one side of the body, pain, warmth, swelling in extremities
What does Forteo do?
First and only drug that works by increasing bone formation
What does Denosumab do?
RANKL inhibitor
What is a side effects of Denosumab?
Osteonecrosis of the jaw
