Prophylaxis of Atherosclerotic CV Disease (ASCVD) Flashcards by Alexis Dormeier | Brainscape

Q

What is the most effective drug for Cholesterol and Triglyceride levels?

A

Statins

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Q

Name a HMG-CoA Reductase Inhibitor

A

Lovastatin

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Q

Name a Bile-Acid Sequestrate

A

Colesevelam

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Q

What are the two other drugs that help lower Cholesterol and triglyceride levels?

A

Ezetimibe

Fibrates

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Q

What are Statins used for?

A

Most effective drug for lowering cholesterol and TG levels

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Q

What is the MOA for Statins?

A

Ultimately increase the number of LDL receptors on hepatic cells

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Q

What are some serious side effects?

A

Myopathy/Rhabdo
Hepatotoxicity
New onset Diabetes

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Q

What do you want to assess before adminstering Atorvastatin (Lipitor)?

A

Liver Function Tests
Viral or Alcoholic Hepatitis
Pregnancy

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Q

When should you take Atorvastatins?

A

In the evening

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Q

What is Colesevelam (Welchol) used for?

A

Reduce LDL cholesterol levels

Adjunts to statins

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Q

What is the MOA of Colesevelam?

A

Increases LDL receptors on hepatocytes

Binds to bile acids In GI tract. Prevents absorption and promotes their excretion

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Q

What are the adverse effects of Colesevelam?

A

Constipation

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Q

What are some drugs that interact with Colesevelam?

A

Thiazide Diuretics
Digoxin
Warfarin

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Q

What do you want to assess for before administering Bile-acid Sequestrants?

A

Obtain lab values for total cholesterol, LDL, HDL, and TG’s

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Q

What is Ezetimibe used for?

A

Adjunct to diet modification to reduce total cholesterol

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Q

What is the MOA of Ezetimibe?

A

acts on small intestines to inhibit dietary cholesterol absorption (prevents cholesterol from entering body)

Q

What are the drugs that interact with Ezetimibe?

A

Statins
Fibrates
Bile-acid Sequestrants

Q

What is the use of Fibrates (Gemfibrozil)?

A

Effective for lowering TG levels and raises HDL