DMARDS

Question 1

What is Methotrexate

Answer 1

Non-biologic DMARDS

Question 2

What are DMARDs used to treat?

Answer 2

Rheumatoid Arthiritis

Question 3

What is the purpose of Methotrexate?

Answer 3

Reduces join destruction and slow disease progression

Question 4

What are the adverse effects of Methotrexate?

Answer 4

Major toxicities such as:
hepatic fibrosis
bone marrow suppression
GI ulceration
pneumonitis
Fetal death

Reduced life expectancy

Question 5

What is Methotrexate excreted?

Answer 5

Through the kidneys

Question 6

What is the MOA of Methotraxate?

Answer 6

Blocks the activation of folic acid which results in suppression of DNA, RNA, and protein synthesis.

Question 7

What assessments do you want to do for a client who is prescribed methotrexate?

Answer 7

Routine blood work
CDC
Mandatory testing of kidney function

Question 8

What is the primary use of Etanercept (Enbrel)?

Answer 8

To treat RA

Question 9

What is the MOA of Etanercept?

Answer 9

Suppresses inflammation by neutralizing Tumor Necrosis Factor

Question 10

What are the adverse effects of etanercept?

Answer 10

Injection site pain
Infection
increased risk of lymphoma
Liver injury

Question 11

What kind of interactions should you check for before administering Etanercept?

Answer 11

Immunosuppressants
Live viruses immunization 
Demyelinating disorders
Severe HF
Active infectons